Ren Gengqing, Wang Yao, Tian Hao, Zhang Kaige, Zhang Han, Liu Xiaoxu, Chen Zhigang
Beijing University of Chinese Medicine, Beijing, 100029, China.
Tsinghua University, Beijing, 100084, China.
Neurol Sci. 2025 May;46(5):1965-1976. doi: 10.1007/s10072-025-08002-3. Epub 2025 Jan 29.
Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by its aggressive nature. Its main clinical features include autonomic dysfunction, Parkinson's disease, and cerebellar ataxia.
We conducted a comprehensive review of the existing literature, exploring studies and reports related to the mechanisms and treatment of multiple system atrophy related neurogenic bladder. Our aim is to provide a detailed and up-to-date overview of its underlying pathophysiology and current therapeutic strategies.
Neurogenic bladder, a common manifestation of MSA, often goes untreated or mistreated, significantly affecting patients' quality of life. Early-stage bladder dysfunction is frequent in MSA patients and correlates with disease severity. The mechanisms of MSA related neurogenic bladder are related to the autonomic nervous system, somatic nerves, frontal cortex, brainstem, and sacral medulla center. Currently, treatment for MSA related neurogenic bladder is mainly symptomatic, and specific drugs are lacking. Further in-depth research is needed to develop more effective therapeutic options that improve patients' quality of life and reduce the risk of complications.
多系统萎缩（MSA）是一种具有侵袭性的进行性神经退行性疾病。其主要临床特征包括自主神经功能障碍、帕金森病和小脑共济失调。
我们对现有文献进行了全面综述，探索与多系统萎缩相关神经源性膀胱的机制和治疗相关的研究及报告。我们的目的是提供其潜在病理生理学和当前治疗策略的详细且最新的概述。
神经源性膀胱是MSA的常见表现，常未得到治疗或治疗不当，严重影响患者生活质量。MSA患者早期膀胱功能障碍很常见，且与疾病严重程度相关。MSA相关神经源性膀胱的机制与自主神经系统、躯体神经、额叶皮质、脑干和骶髓中枢有关。目前，MSA相关神经源性膀胱的治疗主要是对症治疗，缺乏特效药物。需要进一步深入研究以开发更有效的治疗方案，从而改善患者生活质量并降低并发症风险。
