Wu Junmeng, Chen He, Liu Yingjun, Yang Ruotong, An Na
Xi'an Medical University, No. 1, Xinwang Road, Weiyang District, Xi'an, 710021, People's Republic of China.
Department of General Dentistry II, Peking University School and Hospital of Stomatology, Beijing, People's Republic of China.
J Cancer Res Clin Oncol. 2025 Jan 28;151(2):53. doi: 10.1007/s00432-025-06098-w.
This epidemiological study leverages data from the Global Burden of Disease (GBD) database spanning from 1990 to 2021 to analyze the global burden of oral cancer. The research aims to provide a comprehensive assessment of the age-standardized incidence rate (ASIR), age-standardized mortality rate (ASDR), and disability-adjusted life years (DALYs) for oral cancer, examining trends over three decades.
The study used age standardized rate (ASRs) as an indicator of oral cancer epidemiological data. Trend analysis uses estimated annual percentage change (EAPC) to track changes in oral cancer indicators.
The study identifies a global increase in oral cancer incidence, mortality, and DALYs. From 1990 to 2021, the global incidence rate increased significantly from 3.26 (95% UI 3.14-3.41) to 5.34 (95% UI 4.94-5.70), the global mortality rate rose from 1.83 (95% UI 1.73-1.92) to 2.64 (95% UI 2.42-2.84), and the global estimate of DALYs increased from 55.05 (95% UI 52.38-57.97) to 74.44 (95% UI 67.50-80.44). High-risk regions include Palau and certain areas in Asia. Middle SDI regions show the most significant growth, while economically underdeveloped areas like parts of Africa show less significant trends.
The research underscores the need for heightened awareness, surveillance, and prevention efforts, especially in regions with high oral cancer incidence. Policymakers are urged to implement screening programs and public health education to combat the disease.
本流行病学研究利用1990年至2021年全球疾病负担（GBD）数据库中的数据，分析口腔癌的全球负担。该研究旨在全面评估口腔癌的年龄标准化发病率（ASIR）、年龄标准化死亡率（ASDR）和伤残调整生命年（DALYs），并考察三十年来的趋势。
该研究使用年龄标准化率（ASRs）作为口腔癌流行病学数据的指标。趋势分析采用估计年百分比变化（EAPC）来追踪口腔癌指标的变化。
该研究发现全球口腔癌的发病率、死亡率和伤残调整生命年均有所上升。从1990年到2021年，全球发病率从3.26（95%UI 3.14 - 3.41）显著增至5.34（95%UI 4.94 - 5.70），全球死亡率从1.83（95%UI 1.73 - 1.92）升至2.64（95%UI 2.42 - 2.84），全球伤残调整生命年估计值从55.05（95%UI 52.38 - 57.97）增至74.44（95%UI 67.50 - 80.44）。高风险地区包括帕劳和亚洲的某些地区。中等社会人口指数（SDI）地区增长最为显著，而非洲部分地区等经济欠发达地区的趋势则不太明显。
该研究强调需要提高认识、加强监测和预防工作，特别是在口腔癌发病率高的地区。敦促政策制定者实施筛查计划和开展公共卫生教育以对抗该疾病。
