Cost-effectiveness analysis of extended endoscopic lumbar foraminotomy (EELF) and transforaminal lumbar interbody fusion (TLIF): a prospective observational study.

Lumbar foraminal stenosis can be surgically treated by foraminal decompression or facet joint resection and fusion (transforaminal lumbar interbody fusion, TLIF). While conventional foraminal decompression poses a risk of segmental instability, the endoscopic approach (extended endoscopic lumbar foraminotomy, EELF) resects only the ventral part of the facet joint with a horizontal surgical trajectory. A prospective observational study was performed to analyze the cost-effectiveness of EELF versus TLIF. Patients with dominant unilateral radicular pain from lumbar foraminal stenosis at or above L4-5, without severe central stenosis or instability, were included from January 2021 to February 2023. EELF involved sufficient foraminal widening using a reamer, followed by an endoscopic procedure. The primary outcome was the cost per quality-adjusted life year (QALY) gain at postoperative 12 months. Among 26 patients in each group, the primary analysis included 23 EELF patients (mean age: 72 ± 8 years) and 22 TLIF patients (mean age: 70 ± 8 years). EELF was significantly more cost-effective (EELF: $15,536.0 ± 4,190.0/QALY vs. TLIF: $32,869.4 ± 5,429.3/QALY, p < .001) and demonstrated shorter operating times, less blood loss, and shorter length of stay (p < .05), with no significant difference in clinical outcomes. Thus, EELF could be a cost-effective and less invasive alternative for treating lumbar foraminal stenosis.