Bourgkard Eve, Boini Stéphanie, Grzebyk Michel, Dziurla Mathieu, Ferrières Jean, Goldberg Marcel, Ribet Céline, Esquirol Yolande
Department of Occupational Epidemiology, French Research and Safety Institute for the Prevention of Occupational Accidents and Diseases (INRS), Vandœuvre-Les-Nancy, France.
UMR 1295, Paul Sabatier III University-Inserm, CERPOP: Centre for Epidemiology Research in Population Health, Toulouse, France.
BMC Public Health. 2025 Jan 28;25(1):356. doi: 10.1186/s12889-025-21511-2.
The cardiovascular consequences of night work are increasingly well-known. Implementing effective preventive strategies, however, requires further investigation of the effects of exposure duration. This study sought to assess the cumulative dose-effect of night work exposure on the prevalence of cardiovascular risk factors among current and former night workers in France.
We used cross-sectional data from the CONSTANCES cohort to design analyses on 52,234 workers exposed or not exposed to night work during their working life. The cumulative duration of night work exposure was assessed among permanent, rotating and former night workers. BMI, blood pressure, lipids, glycaemia and SCORE2 were measured in health screening centres.
Excess risks of moderate-high SCORE2 were observed for permanent (+ 43%), rotating (+ 72%) and former night workers (+ 101%). Among male permanent night workers, excess risks for obesity (+ 76%) and central obesity (64%) were recorded at five years of exposure and for T2DM (+ 119%) at 10 years of exposure. Male rotating night workers showed excess risks at five years of exposure for obesity/central obesity (about + 45%) and high triglyceridaemia (+ 52%). Female former night workers were at excess risk at five years of exposure for obesity/central obesity (about + 45%), HBP (+ 34%) and low-HDL-C (+ 35%).
The effects on cardiovascular risk factors varied according to the types of night work and within sex groups. Some effects were observed after five years of exposure. These results support the need for early and appropriate monitoring of cardiovascular risk factors among current and former night workers.
夜班工作对心血管系统的影响日益为人所知。然而，要实施有效的预防策略，还需要进一步研究暴露时长的影响。本研究旨在评估法国当前和既往夜班工作者中，夜班工作暴露的累积剂量效应与心血管危险因素患病率之间的关系。
我们使用CONSTANCES队列的横断面数据，对52234名在工作生涯中曾暴露或未暴露于夜班工作的工人进行分析。评估了长期、轮班和既往夜班工作者的夜班工作暴露累积时长。在健康筛查中心测量了体重指数、血压、血脂、血糖和SCORE2。
长期（+43%）、轮班（+72%）和既往夜班工作者（+101%）出现中度至高度SCORE2风险增加。在男性长期夜班工作者中，暴露5年时肥胖（+76%）和中心性肥胖（64%）风险增加，暴露10年时2型糖尿病（+119%）风险增加。男性轮班夜班工作者在暴露5年时出现肥胖/中心性肥胖（约+45%）和高甘油三酯血症（+52%）风险增加。女性既往夜班工作者在暴露5年时出现肥胖/中心性肥胖（约+45%）、高血压（+34%）和低高密度脂蛋白胆固醇（+35%）风险增加。
夜班工作类型不同，且在不同性别群体中，对心血管危险因素的影响也有所不同。暴露5年后观察到了一些影响。这些结果支持有必要对当前和既往夜班工作者的心血管危险因素进行早期和适当监测。
