Singh Kartikey, Mandal Tuhin, Pandey Umesh Pratap, Singh Vikram
Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.
Environment Emission and CRM Section, CSIR-Central Institute of Mining and Fuel Research Dhanbad, Jharkhand, 828108, India.
ACS Biomater Sci Eng. 2025 Feb 10;11(2):742-773. doi: 10.1021/acsbiomaterials.4c02018. Epub 2025 Jan 28.
Carbohydrate-functionalized quantum dots exhibit excellent physical characteristics and enhance the steric interaction with biological cells and tissues. Glycoconjugation of quantum dots promotes aqueous solubility, stability, and reduced immunogenicity. Carbohydrate-protein interactions are involved in various vital processes and provide insight into cellular recognition, cell-to-cell communication, pathogenicity, antigen-antibody recognition, and enzymatic action. Quantum dots are fluorescent materials with rich quantum mechanical and unique optical properties, making them valuable for biomedical applications. Recent advancements in quantum dot materials as biomedical tools have led to the development of carbohydrate-conjugated glyco-functionalized quantum dots. These innovations promise application as nanocarriers, imaging agents, fluorescent probes, and theranostics. This review provides an overview of glyco nanotechnology, emphasizing carbohydrate-conjugated metal-, silicon-, and carbon-based quantum dots as glyco dots and their potential biomedical uses. We hope that this study will address the gap in this field and provide a more precise understanding of the subject.
碳水化合物功能化量子点具有优异的物理特性，可增强与生物细胞和组织的空间相互作用。量子点的糖基化可促进其在水中的溶解性、稳定性并降低免疫原性。碳水化合物与蛋白质的相互作用参与各种重要过程，并为细胞识别、细胞间通讯、致病性、抗原-抗体识别和酶促作用提供了深入了解。量子点是具有丰富量子力学特性和独特光学性质的荧光材料，使其在生物医学应用中具有重要价值。作为生物医学工具的量子点材料的最新进展已导致碳水化合物共轭糖功能化量子点的开发。这些创新有望应用于纳米载体、成像剂、荧光探针和诊疗一体化。本综述概述了糖纳米技术，重点介绍了碳水化合物共轭的基于金属、硅和碳的量子点作为糖点及其潜在的生物医学用途。我们希望这项研究能够填补该领域的空白，并提供对该主题更精确的理解。
