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硅量子点:未来有前途的治疗诊断探针。

Silicon Quantum Dots: Promising Theranostic Probes for the Future.

机构信息

Department of Chemistry, NSS Hindu College, Changanacherry, Kerala-686102, India.

Department of Pharmaceutics, NGSM Institute of Pharmaceutical Science, NITTE Deemed to be University, Mangaluru-575018, India.

出版信息

Curr Drug Targets. 2019;20(12):1255-1263. doi: 10.2174/1389450120666190405152315.

Abstract

Nanotechnology has emerged as one of the leading research areas involving nanoscale manipulation of atoms and molecules. During the past decade, the growth of nanotechnology has been one of the most important developments that have taken place in the biomedical field. The new generation nanomaterials like Quantum dots are gaining much importance. Also, there is a growing interest in the development of nano-theranostics platforms in medical diagnostics, biomedical imaging, drug delivery, etc. Quantum dots are also known as nanoscale semiconductor crystals, with unique electronic and optical properties. Recently, silicon quantum dots are being studied extensively due to their less-toxic, inert nature and ease of surface modification. The silicon quantum dots (2-10nm) are comparatively stable, having optical properties of silicon nanocrystals. This review focuses on silicon quantum dots and their various biomedical applications like drug delivery regenerative medicine and tissue engineering. Also, the processes involved in their modification for various biomedical applications along with future aspects are discussed.

摘要

纳米技术已成为涉及原子和分子纳米级操控的主要研究领域之一。在过去的十年中,纳米技术的发展是生物医学领域最重要的发展之一。新一代纳米材料,如量子点,正变得越来越重要。此外,人们对开发用于医学诊断、生物医学成像、药物输送等的纳米治疗学平台越来越感兴趣。量子点也被称为纳米级半导体晶体,具有独特的电子和光学特性。最近,由于硅量子点的低毒性、惰性和易于表面修饰,它们正被广泛研究。硅量子点(2-10nm)比较稳定,具有硅纳米晶体的光学性质。本文综述了硅量子点及其在药物输送、再生医学和组织工程等各种生物医学应用中的应用。此外,还讨论了它们为各种生物医学应用进行修饰的过程以及未来的发展方向。

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