Cao Zheng, Ou Yuejian, Wang Yufeng, Zheng Yuqing
Affiliated Central Hospital of Huzhou University, Huzhou Central Hospital, Department of Stomatology, Huzhou, Zhejiang, China.
Huzhou University, School of Engineering, Huzhou, Zhejiang, China.
J Med Biochem. 2024 Nov 16;43(6):890-896. doi: 10.5937/jomb0-48581.
The aim of this study was to investigate the association between dental fluorosis occurrence in children and bone metabolism-related indicators, including bone-specific alkaline phosphatase (BALP), osteocalcin (OC), matrix metalloproteinase (MMP-2, MMP-9, MMP-20), and parathyroid hormone (PTH).
A total of 189 cases of school-age children who underwent health examinations in our hospital were enrolled, according to the presence or absence of dental fluorosis. They were divided into the fluorosis group (n=97) and fluoride-free group (n=92), and the serum BALP, OC, MMP-2, MMP-9, MMP-20, and PTH levels of the two groups were compared and relevant clinical data were collected. This study employed multivariate logistic regression to examine the factors associated with the development of dental fluorosis in children.
The urine fluoride levels, BALP, MMP-2, and MMP9 of the children in the fluorosis group were higher than fluoride-free group, and the mother's educational level, per capita annual household income, OC, and PTH were lower than fluoride-free group (P<0.05). Based on Spearman correlation analysis, a positive correlation was identified between the urinary fluoride level, the extent of dental fluorosis, and indicators such as BALP, MMP-2, and MMP-9. (r=0.618, 0.558, 0.567, 0.597, 0.602, 0.571, P<0.001), and negatively correlated with OC and PTH (r=-0.580, -0.603, -0.549, -0.515, P<0.001). As the urinary fluoride level and the extent of dental fluorosis increased, there was a gradual elevation in serum BALP, MMP-2, and MMP-9 levels in children, while OC and PTH levels gradually decreased (P<0.05). After adjusting for confounding factors, including urinary fluoride, maternal education level, and per capita annual household income, multivariate Logistic regression analysis showed that BALP, OC, MMP-2, MMP-9, and PTH were independently associated with the risk of dental fluorosis (P<0.05).
High BALP, MMP-2, MMP-9, low OC, and PTH are independent factors affecting the occurrence of dental fluorosis and are related to the extent of dental fluorosis.
本研究旨在探讨儿童氟斑牙发生与骨代谢相关指标之间的关联，这些指标包括骨特异性碱性磷酸酶（BALP）、骨钙素（OC）、基质金属蛋白酶（MMP - 2、MMP - 9、MMP - 20）和甲状旁腺激素（PTH）。
选取在我院进行健康体检的189例学龄儿童，根据是否患有氟斑牙进行分组。分为氟斑牙组（n = 97）和无氟组（n = 92），比较两组儿童血清BALP、OC、MMP - 2、MMP - 9、MMP - 20及PTH水平，并收集相关临床资料。本研究采用多因素logistic回归分析儿童氟斑牙发生的相关影响因素。
氟斑牙组儿童尿氟水平、BALP、MMP - 2及MMP9高于无氟组，母亲文化程度、家庭人均年收入、OC及PTH低于无氟组（P < 0.05）。Spearman相关分析显示，尿氟水平、氟斑牙程度与BALP、MMP - 2、MMP - 9等指标呈正相关（r = 0.618、0.558、0.567、0.597、0.602、0.571，P < 0.001），与OC及PTH呈负相关（r = - 0.580、- 0.603、- 0.
