Jiang Li, Xu Lulian, Lu Yang, Xu Xu
WuXi Children's Hospital, Department of Endocrine, Wuxi, Jiangsu Province, China.
J Med Biochem. 2024 Nov 16;43(6):860-869. doi: 10.5937/jomb0-48461.
This work focused on the correlation between insulin resistance (IR) and blood lipids (BL) in children with simple obesity, as well as the intervention effects of high-intensity interval training (HIIT) in weight loss in children.
80 children aged 6 to 17 years with simple obesity were selected from our hospital and randomly grouped into two groups. Children in the control (Ctrl) group underwent traditional moderate-intensity continuous training (MICT), while those in the other group received HIIT (HIIT group). After four weeks, body composition-related indicators, BL levels, and IR were measured.
After exercise, children in both groups possessed obvious reductions in body mass index (BMI), body fat percentage (BFP), triglyceride (TG), and homeostasis model assessment of IR (HOMA-IR), demonstrating remarkable differences in contrast to those after intervention (P<0.05). The HIIT group also exhibited considerable differences in waist circumference (WC), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) (P<0.05). After exercise, the HIIT group demonstrated more observable BMI, WC, TG, and HOMA-IR reductions, showing great differences with the Ctrl group (P<0.05). HOMA-IR exhibited positive correlations with TC, TG, and HDL-C but a negative one with LDL-C (P<0.05).
HIIT improved the body composition and BL levels in children with simple obesity, downregulated HOMA-IR, and positively impacted their health status. Furthermore, IR was associated with BL-relevant indicators in children with simple obesity.
本研究聚焦于单纯性肥胖儿童胰岛素抵抗（IR）与血脂（BL）之间的相关性，以及高强度间歇训练（HIIT）对儿童减肥的干预效果。
从我院选取80名6至17岁的单纯性肥胖儿童，随机分为两组。对照组（Ctrl组）儿童进行传统中等强度持续训练（MICT），另一组儿童接受HIIT（HIIT组）。四周后，测量身体成分相关指标、血脂水平和胰岛素抵抗。
运动后，两组儿童的体重指数（BMI）、体脂百分比（BFP）、甘油三酯（TG）和胰岛素抵抗稳态模型评估（HOMA-IR）均明显降低，与干预后相比差异显著（P<0.05）。HIIT组在腰围（WC）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）方面也表现出显著差异（P<0.05）。运动后，HIIT组的BMI、WC、TG和HOMA-IR降低更为明显，与Ctrl组差异显著（P<0.05）。HOMA-IR与TC、TG和HDL-C呈正相关，与LDL-C呈负相关（P<0.05）。
HIIT改善了单纯性肥胖儿童的身体成分和血脂水平，下调了HOMA-IR，并对他们的健康状况产生了积极影响。此外，IR与单纯性肥胖儿童的血脂相关指标有关。
