Graceli Jones B, Dettogni Raquel S, Merlo Eduardo, Niño Oscar, da Costa Charles S, Zanol Jordana F, Ríos Morris Eduardo A, Miranda-Alves Leandro, Denicol Anna C
Department of Morphology, Health Sciences Center, Federal University of Espirito Santo. Av. Marechal Campos, 1468, CEP: 290440-090 Vitória, ES, Brazil.
Laboratory of Experimental Endocrinology-LEEx, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil. Graduate Program in Endocrinology, Faculty of Medicine, Federal University of Rio de Janeiro, Brazil.
Mol Cell Endocrinol. 2020 Dec 1;518:110997. doi: 10.1016/j.mce.2020.110997. Epub 2020 Aug 22.
The hypothalamic-pituitary axis (HP axis) plays a critical and integrative role in the endocrine system control to maintain homeostasis. The HP axis is responsible for the hormonal events necessary to regulate the thyroid, adrenal glands, gonads, somatic growth, among other functions. Endocrine-disrupting chemicals (EDCs) are a worldwide public health concern. There is growing evidence that exposure to EDCs such as bisphenol A (BPA), some phthalates, polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and biphenyls (PBBs), dichlorodiphenyltrichloroethane (DDT), tributyltin (TBT), and atrazine (ATR), is associated with HP axis abnormalities. EDCs act on hormone receptors and their downstream signaling pathways and can interfere with hormone synthesis, metabolism, and actions. Because the HP axis function is particularly sensitive to endogenous hormonal changes, disruptions by EDCs can alter HP axis proper function, leading to important endocrine irregularities. Here, we review the evidence that EDCs could directly affect the mammalian HP axis function.
下丘脑 - 垂体轴（HP轴）在维持内环境稳定的内分泌系统控制中发挥着关键的整合作用。HP轴负责调节甲状腺、肾上腺、性腺、躯体生长等功能所需的激素活动。内分泌干扰化学物质（EDCs）是一个全球性的公共卫生问题。越来越多的证据表明，接触双酚A（BPA）、某些邻苯二甲酸盐、多氯联苯（PCBs）、多溴二苯醚（PBDEs）和多溴联苯（PBBs）、二氯二苯三氯乙烷（DDT）、三丁基锡（TBT）和莠去津（ATR）等EDCs与HP轴异常有关。EDCs作用于激素受体及其下游信号通路，可干扰激素的合成、代谢和作用。由于HP轴功能对内源性激素变化特别敏感，EDCs的干扰可改变HP轴的正常功能，导致重要的内分泌紊乱。在此，我们综述了EDCs可能直接影响哺乳动物HP轴功能的证据。
