二甲双胍通过AMPK途径下调自噬来改善糖尿病大鼠的周围神经病变。
Metformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the AMPK pathway.
作者信息
You Fangqin, Xie Diya, Li Cheng, Yang Lihang, Liu Fengmin
机构信息
Fuzhou First General Hospital Affiliated with Fujian Medical University Department of General Surgery FuzhouFujian China Department of General Surgery, Fuzhou First General Hospital Affiliated with Fujian Medical University, Fuzhou, Fujian, China.
Fuzhou First General Hospital Affiliated with Fujian Medical University Department of Endocrinology FuzhouFujian China Department of Endocrinology, Fuzhou First General Hospital Affiliated with Fujian Medical University, Fuzhou, Fujian, China.
出版信息
Arch Endocrinol Metab. 2024 Nov 6;68(Spec Issue):e240137. doi: 10.20945/2359-4292-2024-0137. eCollection 2024.
OBJECTIVE
Diabetic neuropathy (DN) is an important complication of diabetes mellitus. Autophagy is considered to be potentially involved in the regulation of DN. Metformin is broadly utilized in the first-line treatment of diabetes. The present work aimed to assess whether and how metformin exerts protective effects in DN.
MATERIALS AND METHODS
A DN rat model induced by streptozotocin (STZ) was established. Metformin was administered to examine its effect on sciatic nerve pathology, and the possible mechanisms involved in this process were explored.
RESULTS
Morphological damage was observed in sciatic nerve samples from diabetic animals, accompanied by decreased p-AMPK expression and increased LC-3 levels. Notably, metformin ameliorated the morphological changes in the sciatic nerve by downregulating autophagy via p-AMPK upregulation.
CONCLUSIONS
These results indicate that metformin attenuates peripheral neuropathy in diabetic rats by regulating autophagy.
目的
糖尿病神经病变（DN）是糖尿病的一种重要并发症。自噬被认为可能参与DN的调节。二甲双胍广泛用于糖尿病的一线治疗。本研究旨在评估二甲双胍是否以及如何在DN中发挥保护作用。
材料与方法
建立链脲佐菌素（STZ）诱导的DN大鼠模型。给予二甲双胍以检测其对坐骨神经病理学的影响，并探讨该过程中可能涉及的机制。
结果
在糖尿病动物的坐骨神经样本中观察到形态学损伤，同时伴有p-AMPK表达降低和LC-3水平升高。值得注意的是，二甲双胍通过上调p-AMPK下调自噬，改善了坐骨神经的形态学变化。
结论
这些结果表明，二甲双胍通过调节自噬减轻糖尿病大鼠的周围神经病变。
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