Tan Zhenkun, Ping Junjiao, Zhang Ying, Kong Chuijia, Luo Jiali, Liu Xinxia
Department of Psychiatry, Third People's Hospital of Zhongshan City, Zhongshan, China.
Front Psychiatry. 2025 Jan 14;15:1469671. doi: 10.3389/fpsyt.2024.1469671. eCollection 2024.
To investigate the correlation between BDNF gene polymorphism, BDNF levels, and susceptibility to mild cognitive impairment (MCI).
In this study, we investigated 107 elderly adults individuals from a community in Zhongshan, Guangdong Province, with an average age of 73.17 ± 7.081 years. The participants included 52 patients with Mild Cognitive Impairment due to Alzheimer's Disease and 55 cognitively normal elderly adults control subjects. The two groups were matched based on gender, age, and education level. We assessed their cognitive functions and analyzed their genotypes and serum BDNF levels. Analysis of covariance (ANCOVA) was used to evaluate the differences in serum BDNF levels between the MCI group and the control group. Multivariate linear regression was utilized to analyze the association between BDNF levels and susceptibility to MCI, as well as cognitive functions. Multivariate logistic regression was employed to investigate the association between BDNF gene polymorphisms and the risk of developing MCI, along with their interactions.
The ANCOVA analysis indicated that there was no significant difference in serum BDNF levels between the MCI group and the control group ( > 0.05). Correlation analysis revealed a negative correlation between Mini-Mental Status Examination (MMSE) total scores and MCI ( = -0.461, = 0.001), with significant correlations observed in orientation ( = -0.420, = 0.002). Multiple linear regression analysis showed that specific polymorphisms, including rs7103411 (CT+TT vs. CC), rs6265 (CT and CT+TT vs. CC), rs11030104 (AG and AG+GG vs. AA), and rs988748 (CG+CC vs. GG), were significantly associated with decreased serum BDNF levels ( < 0.05). Multivariate logistic regression showed that rs7103411 polymorphism was associated with susceptibility to MCI; individuals with the CT or CC genotype had a 0.370 times lower risk of developing MCI compared to those with the TT genotype ( = 0.370, 95% : 0.141-0.970, = 0.043). A significant interaction was found between rs7103411 and social activity, which influenced the risk of developing MCI. Specifically, individuals with the CT or TT genotype of rs7103411 who engaged in social activities had a significantly lower risk of developing MCI ( = 0.32, 95% : 0.117-0.878, = 0.027).
This study indicates that BDNF rs7103411、rs6265、rs11030104 and rs988748 are associated with decreased serum BDNF levels in MCI patients. Individuals carrying the TT genotype in the BDNF rs7103411 gene are associated with an increased susceptibility to MCI. Individuals with the rs7103411 CT or TT genotype who participated in social activities showed a significantly reduced risk of developing MCI, suggesting that the interaction between the BDNF rs7103411 genotype and social activity can help reduce the risk of MCI.
探讨脑源性神经营养因子（BDNF）基因多态性、BDNF水平与轻度认知障碍（MCI）易感性之间的相关性。
在本研究中，我们调查了来自广东省中山市一个社区的107名老年人，平均年龄为73.17±7.081岁。参与者包括52例因阿尔茨海默病导致的轻度认知障碍患者和55名认知正常的老年对照受试者。两组在性别、年龄和教育水平上进行了匹配。我们评估了他们的认知功能，并分析了他们的基因型和血清BDNF水平。采用协方差分析（ANCOVA）评估MCI组和对照组血清BDNF水平的差异。利用多元线性回归分析BDNF水平与MCI易感性以及认知功能之间的关联。采用多元逻辑回归研究BDNF基因多态性与发生MCI风险之间的关联及其相互作用。
ANCOVA分析表明，MCI组和对照组血清BDNF水平无显著差异（>0.05）。相关性分析显示简易精神状态检查表（MMSE）总分与MCI呈负相关（=-0.461，=0.001），在定向方面有显著相关性（=-0.420，=0.002）。多元线性回归分析表明，包括rs7103411（CT+TT与CC）、rs6265（CT以及CT+TT与CC）、rs11030104（AG和AG+GG与AA）和rs988748（CG+CC与GG）在内的特定多态性与血清BDNF水平降低显著相关（<0.05）。多元逻辑回归显示，rs7103411多态性与MCI易感性相关；与TT基因型个体相比，携带CT或CC基因型的个体发生MCI的风险低0.370倍（=0.370，95%：0.141-0.970，=0.043）。发现rs7103411与社会活动之间存在显著相互作用，这影响了发生MCI的风险。具体而言，参与社会活动的rs7103411的CT或TT基因型个体发生MCI的风险显著较低（=0.32，95%：0.117-0.878，=0.027）。
本研究表明，BDNF rs7103411、rs6265、rs11030104和rs988748与MCI患者血清BDNF水平降低有关。BDNF rs7103411基因中携带TT基因型的个体与MCI易感性增加有关。参与社会活动的rs7103411 CT或TT基因型个体发生MCI的风险显著降低，表明BDNF rs7103411基因型与社会活动之间的相互作用有助于降低MCI风险。
