Ngo-Huang An, Fricke Brian C, Schadler Keri L, Parker Nathan H
Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Unit 1414, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Department of Physical Medicine and Rehabilitation, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive - MSC 7798, San Antonio, TX, USA.
Curr Phys Med Rehabil Rep. 2021 Sep;9(3):136-141. doi: 10.1007/s40141-021-00316-5. Epub 2021 Aug 14.
This report reviews the preliminary evidence of how exercise may alter the tumor microenvironment and tumor biology in animal and human studies; and how to incorporate this information in clinical practice of oncology rehabilitation.
Potential mechanisms explaining the impact of exercise on the tumor microenvironment include activating and mobilizing immune cells, reducing inflammation, and modifying tumor vasculature which enhances the delivery of anticancer therapies. Pre-clinical data translates to promising preliminary data in human studies; however, randomized, controlled trials in patients are limited.
Despite the paucity of robust data demonstrating the beneficial effects of exercise on tumor biology, the strong observational and epidemiological data and limited interventional trials encourage the continued prescribing of exercise by rehabilitation professionals for cancer survivors.
本报告回顾了运动如何在动物和人体研究中改变肿瘤微环境及肿瘤生物学的初步证据；以及如何将这些信息纳入肿瘤康复临床实践。
解释运动对肿瘤微环境影响的潜在机制包括激活和调动免疫细胞、减轻炎症以及改变肿瘤血管，从而增强抗癌治疗的递送。临床前数据转化为人体研究中有前景的初步数据；然而，针对患者的随机对照试验有限。
尽管缺乏有力数据证明运动对肿瘤生物学有有益影响，但强有力的观察性和流行病学数据以及有限的干预性试验鼓励康复专业人员继续为癌症幸存者开具运动处方。
