血小板计数与早产儿视网膜病变：一项系统评价和荟萃分析
Platelet count and retinopathy of prematurity, a systematic review and meta-analysis.
作者信息
Zeng Qian, Wang Ling, Li Yurong, Yue Yuanyuan, Lv Xin
机构信息
Clinical Laboratory, Children's Hospital Affiliated to Shandong University, Jinan, China.
Clinical Laboratory, Jinan Children's Hospital, Jinan, China.
出版信息
Front Pediatr. 2025 Jan 14;12:1413271. doi: 10.3389/fped.2024.1413271. eCollection 2024.
OBJECTIVE
This study aims to investigate the relationship between platelet count (PLT) and retinopathy of prematurity (ROP), with the goal of identifying a straightforward screening method for the early detection of ROP.
METHODS
A systematic search was conducted in PubMed, EMBASE, Web of Science, Cochrane Library, and ClinicalTrials.gov from January 2005 to 26 September 2023. Subsequently, a subgroup analysis was performed.
RESULTS
This meta-analysis included ten studies involving 1762 neonates, with 747 cases of ROP identified. The pooled analysis indicated a significant decrease in mean platelet count among the ROP group compared to the non-ROP group (mean difference: -18.65, 95% confidence interval: -22.80 to -14.50, < .00001). Subgroup analysis indicated that the heterogeneity in the results can be attributed to factors such as the location of the studies, gestational age (GA), and publication time.
CONCLUSION
Decreased PLT counts may be associated with the occurrence of ROP. The PLT count should be standardized according to the detection location, detection time and GA.
目的
本研究旨在探讨血小板计数（PLT）与早产儿视网膜病变（ROP）之间的关系，以确定一种简单的筛查方法用于ROP的早期检测。
方法
于2005年1月至2023年9月26日在PubMed、EMBASE、Web of Science、Cochrane图书馆和ClinicalTrials.gov进行了系统检索。随后进行了亚组分析。
结果
该荟萃分析纳入了10项研究，涉及1762例新生儿，其中确诊ROP 747例。汇总分析表明，与非ROP组相比，ROP组的平均血小板计数显著降低（平均差值：-18.65，95%置信区间：-22.80至-14.50，P<0.00001）。亚组分析表明，结果的异质性可归因于研究地点、胎龄（GA）和发表时间等因素。
结论
血小板计数降低可能与ROP的发生有关。应根据检测地点、检测时间和GA对血小板计数进行标准化。
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