Chinawa Josephat M, Ossai Edmund N, Chinawa Awoere T, Onyia Jude T
Department of Paediatrics, College of Medicine, University of Nigeria Ituku/Ozalla and University of Nigeria Teaching Hospital Ituku/Ozalla, Enugu, Enugu State, Nigeria.
Department of Community Medicine, Ebonyi State University, Abakiliki, Ebonyi state,Nigeria.
Malawi Med J. 2025 Jan 13;36(4):283-287. doi: 10.4314/mmj.v36i4.7. eCollection 2025 Jan.
Children with Tetralogy of Fallot (TOF) usually present with right heart abnormalities, however much is not known if these children presents with left ventricular dysfunction.
This article is aimed to ascertain the left ventricular function of children with TOF compared with those without any congenital heart disease. It also elicits the correlation if any, between left ventricular mass and descending aorta blood flow.
This is a comparative study involving 91 children with TOF with age and gender matched control. Echocardiographic evaluation of left ventricular function and their parameters in children with TOF were compared with controls. The data was analyzed with the IBM SPSS statistics for windows, version 20 (IBM Corp, Chicago).
The mean LVIDd of subjects without TOF, 25.7±10.1 was higher than that of those with TOF, 21.2±7.1 and the difference in mean was found to be statistically significant, (Student t=3.455, p=0.001). The mean EF of respondents with TOF, 61.9±19.3 was lower than that of subjects without TOF, 67.2±9.3 and the difference in mean was found to be statistically significant, (Student t=2.333, p=0.021). The mean FS of respondents with TOF, 43.1±16.6 was significantly lower than that of respondents without FS 46.7±8.2 (Student t=3.519, p=0.001). The mean velocity of respondents without TOF, 1.3±0.3 was significantly higher than that of respondents with TOF, 1.2±0.2. (Student t=4.199, p<0.001).For respondents who had TOF, there was a weak negative correlation between LV mass and velocity, increases with LV mass correlates with decreases in velocity but this was not found to be statistically significant, (n=63, r=-0.214, p=0.093).
Though it is generally known that children with TOF present with right ventricular dysfunction, however this study has shown that they also present with various degrees of left ventricular systolic abnormalities. Though left ventricular systolic function in children with TOF is lower than that in normal children, all values still fall within normal refrence ranges.
法洛四联症（TOF）患儿通常存在右心异常，然而这些患儿是否存在左心室功能障碍尚不清楚。
本文旨在确定TOF患儿与无先天性心脏病患儿相比的左心室功能。同时探究左心室质量与降主动脉血流之间是否存在相关性（若有）。
这是一项对比研究，纳入了91例TOF患儿，并设置了年龄和性别匹配的对照组。对TOF患儿的左心室功能及其参数进行超声心动图评估，并与对照组进行比较。数据采用IBM SPSS Statistics for Windows 20版软件（IBM公司，芝加哥）进行分析。
无TOF受试者的平均左室内径舒张末期（LVIDd）为25.7±10.1，高于TOF患儿的21.2±7.1，且均值差异具有统计学意义（学生t检验=3.455，p=0.001）。TOF患儿的平均射血分数（EF）为61.9±19.3，低于无TOF受试者的67.2±9.3，均值差异具有统计学意义（学生t检验=2.333，p=0.021）。TOF患儿的平均缩短分数（FS）为43.1±16.6，显著低于无TOF受试者的46.7±8.2（学生t检验=3.519，p=0.001）。无TOF受试者的平均速度为1.3±0.3，显著高于TOF患儿的1.2±0.2（学生t检验=4.199，p<0.001）。对于患有TOF的受试者，左心室质量与速度之间存在弱负相关，左心室质量增加与速度降低相关，但未发现具有统计学意义（n=63，r=-0.214，p=0.093）。
尽管通常认为TOF患儿存在右心室功能障碍，但本研究表明他们也存在不同程度的左心室收缩异常。虽然TOF患儿的左心室收缩功能低于正常儿童，但所有数值仍在正常参考范围内。
