Debruyne D, Moulin M A, Carmes C, Beguin J A, Locker B
Eur J Clin Pharmacol. 1985;27(6):733-5. doi: 10.1007/BF00547058.
Arthroscopy was carried out after subcutaneous injection of lignocaïne to produce local anaesthesia, using controlled pressure-irrigation with bupivacaïne, followed by final rinsing with an isotonic solution. This procedure, which was painless for the patient and had no systemic toxic effects, gave very good distension of the joint and clear visualization of its structure. A sharp peak in the serum bupivacaïne level (Cmax: 76.2 ng/ml) was observed only 5 min after the start of the irrigation, which was attributed to synovial resorption. This was followed by a slight increase in blood concentration 4 to 5 h after the end of the arthroscopy, probably as a result of absorption by the peripheral soft tissues. Bupivacaïne concentrations never exceeded 350 ng/ml (much lower than the toxic level). The drug persisted in blood for 36 to 48 h (terminal half-life 12.1 h).
在皮下注射利多卡因以产生局部麻醉后进行关节镜检查，使用布比卡因进行控制压力冲洗，最后用等渗溶液冲洗。该操作对患者无痛且无全身毒性作用，能使关节很好地扩张并清晰显示其结构。仅在冲洗开始后5分钟观察到血清布比卡因水平出现一个尖峰（Cmax：76.2 ng/ml），这归因于滑膜吸收。随后在关节镜检查结束后4至5小时血药浓度略有升高，可能是外周软组织吸收的结果。布比卡因浓度从未超过350 ng/ml（远低于中毒水平）。药物在血液中持续存在36至48小时（终末半衰期12.1小时）。
