Resseguie L J, Hick J F, Bruen J A, Noller K L, O'Fallon W M, Kurland L T
Fertil Steril. 1985 Apr;43(4):514-9. doi: 10.1016/s0015-0282(16)48490-6.
Comparison of a cohort of 988 offspring exposed in utero to exogenous progestins with a matched cohort of unexposed offspring did not result in detection of an association of congenital anomalies with exposure. The conclusions are based primarily on outcomes of pregnancy with exposure to progesterone and 17 alpha-hydroxyprogesterone caproate, and may not apply to androgenic progestins. Offspring exposed to combinations of progestins and estrogens were excluded from this study and may have a different distribution of anomalies.
将988名子宫内暴露于外源性孕激素的后代队列与匹配的未暴露后代队列进行比较，未发现先天性异常与暴露之间存在关联。这些结论主要基于暴露于黄体酮和己酸17α-羟孕酮的妊娠结局，可能不适用于雄激素类孕激素。暴露于孕激素和雌激素组合的后代被排除在本研究之外，可能有不同的异常分布。
