Mansouri Maysam, Fussenegger Martin
Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland; Faculty of Science, University of Basel, Mattenstrasse 26, 4058 Basel, Switzerland.
Cell Chem Biol. 2025 Apr 17;32(4):521-528. doi: 10.1016/j.chembiol.2025.01.003. Epub 2025 Jan 28.
Human body cells and our daily electronic devices both communicate information within their distinct worlds by regulating the flow of electrons across specified membranes. While electronic devices depend on the flow of electrons generated by conductive materials to communicate within a digital network, biological systems use ion gradients, created in analog biochemical reactions, to trigger biological data transmission throughout multicellular systems. Electrogenetics is an emerging concept in synthetic biology in which electrons generated by digital electronic devices program customized electron-responsive biological units within living cells. In this paper, we outline endeavors to design direct electrogenetic interfaces to control cell behaviors in therapeutically engineered mammalian cells. We also discuss prospects for the world of electrogenetics, focusing on how to engineer the next generation of therapeutic cells controlled by electronic devices and the internet of the body.
人体细胞和我们日常的电子设备都通过调节电子在特定膜上的流动，在各自不同的世界中传递信息。电子设备依靠导电材料产生的电子流在数字网络中进行通信，而生物系统则利用模拟生化反应中产生的离子梯度，在多细胞系统中触发生物数据传输。电遗传学是合成生物学中一个新兴的概念，在这个概念中，数字电子设备产生的电子对活细胞内定制的电子响应生物单元进行编程。在本文中，我们概述了设计直接电遗传接口以控制治疗工程哺乳动物细胞行为的相关努力。我们还讨论了电遗传学领域的前景，重点关注如何设计由电子设备和人体物联网控制的下一代治疗性细胞。
