Magri M H, Solari A, Billard R, Reinaud P
Gen Comp Endocrinol. 1985 Mar;57(3):411-21. doi: 10.1016/0016-6480(85)90223-0.
The influence of testosterone on plasma and pituitary levels of gonadotrophin (GTH) as well as on gonadal development was studied in immature rainbow trout. Among the animals receiving a testosterone-cocoa butter implant (200 micrograms) at the age of 5 months, gonadal puberty occurred 8 months later in half of the males (opposite to the controls which remained immature) and the beginning of oocyte maturation was observed in only one female. These animals were characterized by a higher pituitary GTH level. Owing to the multivariate statistical analyses made, it was possible to provide evidence for the presence of two populations with different reactions to the same steroid treatment. They also confirmed the existence of a positive testosterone feedback, in the male, leading to a precocious gonadal development. The pituitary GTH load obtained with 200 micrograms of testosterone seemed to be related to the age of first maturation. The secretion of an appropriate level of GTH resulting in the stimulation of gametogenesis required the availability of a relatively large pituitary GTH level and seemed to be possible because the animals were already in the pubertal period. The fact that the highest pituitary GTH level of the treated lot was found in the only female showing a beginning of sexual maturation suggests that testosterone may also act in females.
在未成熟的虹鳟鱼中研究了睾酮对促性腺激素（GTH）的血浆和垂体水平以及性腺发育的影响。在5个月大时接受睾酮-可可脂植入物（200微克）的动物中，8个月后，一半的雄性出现性腺青春期（与仍未成熟的对照组相反），仅在一只雌性中观察到卵母细胞成熟的开始。这些动物的垂体GTH水平较高。由于进行了多变量统计分析，有可能证明存在对相同类固醇处理有不同反应的两个群体。它们还证实了在雄性中存在睾酮正反馈，导致性腺早熟。用200微克睾酮获得的垂体GTH负荷似乎与首次成熟的年龄有关。分泌适当水平的GTH以刺激配子发生需要相对较高的垂体GTH水平，并且由于动物已经处于青春期，这似乎是可能的。在唯一一只显示性成熟开始的雌性中发现处理组的垂体GTH水平最高，这一事实表明睾酮也可能在雌性中起作用。
