Wu Gang, Zhong Chunyan, Tian Xiaohui, Zha Lisha, Hou Lingmi, Feng Xiaoqiang
Department of Hepatobiliary Pancreatic Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.
Department of Ultrasound, Chongqing Health Center for Women and Children, Chongqing, China.
Int J Biol Macromol. 2025 Apr;303:140442. doi: 10.1016/j.ijbiomac.2025.140442. Epub 2025 Jan 27.
Hyaluronic acid (HA)-derived hydrogels demonstrate a significant development in the biomedical uses, especially in cancer treatment and wound repair. Cancer continues to be one of the leading causes of death worldwide, with current therapies frequently impeded by lack of specificity, side effects, and the emergence of resistance. HA hydrogels, characterized by their distinctive three-dimensional structure, hydrophilic nature, and biocompatibility, develop an advanced platform for precise drug delivery, improving therapeutic results while minimizing systemic toxicity. These hydrogels facilitate the controlled release of drugs, genes, and various therapeutic substances, enhancing the effectiveness of chemotherapy, radiotherapy, and immunotherapy. Additionally, they can be designed to react to stimuli such as pH, light, and magnetic fields, enhancing their therapeutic capabilities. In the process of wound healing, the hydrophilic and porous characteristics of HA hydrogels establish a moist environment encouraging cell growth and contributes to the tissue recovery. By imitating the extracellular matrix, they promote tissue regeneration, improve angiogenesis, and influence immune reactions. This review examines the various functions of HA-based hydrogels in cancer treatment and wound healing, highlighting their advancement, applications, and ability to change existing therapeutic methods in these important health sectors.
透明质酸（HA）衍生的水凝胶在生物医学应用领域取得了显著进展，尤其是在癌症治疗和伤口修复方面。癌症仍然是全球主要死因之一，当前的治疗方法常常因缺乏特异性、副作用以及耐药性的出现而受到阻碍。HA水凝胶具有独特的三维结构、亲水性和生物相容性，为精确给药提供了一个先进的平台，在将全身毒性降至最低的同时提高治疗效果。这些水凝胶有助于药物、基因和各种治疗物质的控释，增强化疗、放疗和免疫疗法的效果。此外，它们可以被设计成能对pH值、光和磁场等刺激做出反应，从而增强其治疗能力。在伤口愈合过程中，HA水凝胶的亲水性和多孔特性营造了一个有利于细胞生长的湿润环境，有助于组织恢复。通过模仿细胞外基质，它们促进组织再生，改善血管生成，并影响免疫反应。本综述探讨了基于HA的水凝胶在癌症治疗和伤口愈合中的各种功能，并着重介绍了它们在这些重要健康领域的进展、应用以及改变现有治疗方法的能力。
