Chhillar Anish, Jaiswal Amit
School of Biosciences and Bioengineering, Indian Institute of Technology Mandi, Kamand, Mandi, Himachal Pradesh, 175075, India.
Adv Healthc Mater. 2025 Feb;14(4):e2404255. doi: 10.1002/adhm.202404255. Epub 2024 Dec 25.
Diabetic wounds, particularly diabetic foot ulcers (DFUs), are significant threats to human well-being due to their impaired healing from poor circulation and high blood sugar, increased risk of infection and potential for severe complications like amputation, all compounded by peripheral neuropathy and chronic inflammation. Most therapies and dressings for DFUs focus on one symptom at a time, however, multifunctional smart self-healing hydrogels can withstand multifactorial motional diabetic wounds. Motional wounds are easy-to-split wounds that experience tension, compression, and movement caused by stress now and then. Hyaluronic acid (HA) based self-healing hydrogels stand out among other biomaterials due to their ability to cover irregular wound surfaces, maintain a moist environment, repair themselves when ruptured, and exhibit excellent biocompatibility. These self-healing hydrogels can repair damages caused by movement and recover the functional properties during healing. These hydrogels can also act as therapeutic delivery vehicles and tissue regeneration systems. This review demonstrates the potential of HA-based self-healing hydrogels for diabetic wound healing. Due to its self-healing capabilities, these hydrogels offer a customized therapeutic approach for motional diabetic wounds. The review also critically examines the challenges and future directions for HA-based self-healing hydrogels in diabetic wound healing.
糖尿病伤口，尤其是糖尿病足溃疡（DFU），由于血液循环不良和高血糖导致愈合受损、感染风险增加以及截肢等严重并发症的可能性，对人类健康构成重大威胁，而周围神经病变和慢性炎症又使这些问题更加复杂。然而，大多数针对DFU的治疗方法和敷料一次只关注一种症状，多功能智能自愈水凝胶却可以应对多因素动态糖尿病伤口。动态伤口是容易裂开的伤口，会不时受到由压力引起的张力、挤压和移动。基于透明质酸（HA）的自愈水凝胶在其他生物材料中脱颖而出，因为它们能够覆盖不规则的伤口表面、保持湿润环境、破裂时自我修复，并具有出色的生物相容性。这些自愈水凝胶可以修复由移动造成的损伤，并在愈合过程中恢复功能特性。这些水凝胶还可以作为治疗性给药载体和组织再生系统。本综述展示了基于HA的自愈水凝胶在糖尿病伤口愈合方面的潜力。由于其自愈能力，这些水凝胶为动态糖尿病伤口提供了一种定制的治疗方法。该综述还批判性地审视了基于HA的自愈水凝胶在糖尿病伤口愈合方面面临的挑战和未来方向。
