海马体中扩大的血管周围间隙与2型糖尿病患者的记忆功能相关。

The enlarged perivascular spaces in the hippocampus is associated with memory function in patients with type 2 diabetes mellitus.

作者信息

Pan Peichun, Zhang Dongsheng, Li Jing, Tang Min, Yan Xuejiao, Zhang Xin, Wang Man, Lei Xiaoyan, Zhang Xiaoling, Gao Jie

机构信息

Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.

Department of Graduate, Shaanxi University of Traditional Chinese Medicine, Xianyang, China.

出版信息

Sci Rep. 2025 Jan 29;15(1):3644. doi: 10.1038/s41598-025-87841-8.

DOI:10.1038/s41598-025-87841-8

PMID:39880912

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11779836/

Abstract

Early detection of cognitive dysfunction in patients with type 2 diabetes mellitus (T2DM) is important for preventive measures due to the lack of effective treatments. The purpose of this study is to investigate the relationship between enlarged perivascular space in the hippocampus (H-EPVS) and cognitive performance in patients with T2DM, and to determine whether it can serve as an imaging marker for cognitive dysfunction. 66 T2DM patients with cognitive impairment (T2DM-CI) and 71 T2DM patients with normal cognitive function (T2DM-NC) underwent cranial MRI scans and comprehensive neuropsychological assessments. H-EPVS counts were visually calculated on T2WI imaging according to a previous scale. The differences in the counts of H-EPVS, demographic data, laboratory test results, and cognitive assessment scores between the two groups were compared. The partial correlation analysis was used to explore the relationship between H-EPVS and glymphatic system function (indicated by the DTI-ALPS index), as well as markers of CSVD. Multiple linear regression models were conducted to explore the association between H-EPVS and cognitive functions. Compared with the T2DM-NC group, T2DM-CI exhibited significantly higher counts of H-EPVS in both the total (sum of the left and right side) and left side (P < 0.001). The T2DM-CI group had lower DTI-ALPS index and RAVLT total score. The total H-EPVS counts were significantly correlated with the DTI-ALPS index (r = - 0.240, P = 0.005), BG-EPVS (r = 0.325, P < 0.001), and CSO-EPVS (r = 0.183, P = 0.033). Multiple linear regression showed the total H-EPVS counts exhibited a negative correlation with MMSE (β = - 0.324, 95% CI: - 0.091, - 0.320), immediate memory (β = - 0.380, 95% CI: - 0.673, - 1.766) and delayed recall (β = - 0.252, 95% CI: - 0.052, - 0.463). H-EPVS may serve as a potential neuroimaging biomarker for cognitive impairment in patients with T2DM, warranting further investigation and validation in future studies.

摘要

由于缺乏有效的治疗方法，早期发现2型糖尿病（T2DM）患者的认知功能障碍对于预防措施至关重要。本研究的目的是探讨海马体血管周围间隙增宽（H-EPVS）与T2DM患者认知表现之间的关系，并确定其是否可作为认知功能障碍的影像学标志物。66例有认知障碍的T2DM患者（T2DM-CI）和71例认知功能正常的T2DM患者（T2DM-NC）接受了头颅MRI扫描和全面的神经心理学评估。根据先前的量表在T2WI成像上直观计算H-EPVS计数。比较两组之间H-EPVS计数、人口统计学数据、实验室检查结果和认知评估分数的差异。采用偏相关分析探讨H-EPVS与类淋巴系统功能（由DTI-ALPS指数表示）以及脑小血管病（CSVD）标志物之间的关系。进行多元线性回归模型以探讨H-EPVS与认知功能之间的关联。与T2DM-NC组相比，T2DM-CI组的H-EPVS总计数（左右两侧之和）和左侧计数均显著更高（P < 0.001）。T2DM-CI组的DTI-ALPS指数和雷伊听觉词语学习测验（RAVLT）总分较低。H-EPVS总计数与DTI-ALPS指数（r = - 0.240，P = 0.005）、脑桥血管周围间隙增宽（BG-EPVS，r = 0.325，P < 0.001）和半卵圆中心血管周围间隙增宽（CSO-EPVS，r = 0.183，P = 0.033）显著相关。多元线性回归显示，H-EPVS总计数与简易精神状态检查表（MMSE，β = - 0.324，95%可信区间：- 0.091，- 0.320）、即刻记忆（β = - 0.380，95%可信区间：- 0.673，- 1.766）和延迟回忆（β = - 0.252，95%可信区间：- 0.052，- 0.463）呈负相关。H-EPVS可能是T2DM患者认知障碍的潜在神经影像学生物标志物，值得在未来研究中进一步研究和验证。