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MRI 测量脑内海马体体积与轻度认知障碍和阿尔茨海默病的关系：系统评价和荟萃分析。

MRI measurements of brain hippocampus volume in relation to mild cognitive impairment and Alzheimer disease: A systematic review and meta-analysis.

机构信息

Department of Rehabilitation, Taizhou Integrated Chinese and West Medicine Hospital, Taizhou, Zhejiang, China.

Department of Neurology, Taizhou Integrated Chinese and West Medicine Hospital, Taizhou, Zhejiang, China.

出版信息

Medicine (Baltimore). 2023 Sep 8;102(36):e34997. doi: 10.1097/MD.0000000000034997.

DOI:10.1097/MD.0000000000034997
PMID:37682140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10489245/
Abstract

BACKGROUND

This is the first meta-analysis conducted to compare the hippocampal volume measured by magnetic resonance imaging (MRI) in healthy normal subjects, mild cognitive impairment (MCI) and Alzheimer disease (AD), and to analyze the relationship between hippocampal volume changes and MCI and AD.

METHODS

English literatures published from January 2004 to December 2006 were extracted from PubMed, Embase, Wanfang Medical, and China National Knowledge Infrastructure databases. Statistical analysis was carried out with Stata/SE 16.0 software.

RESULTS

The smaller the volume of the hippocampus measured by MRI, the more severe the cognitive impairment or AD. Different MRI post-measurement correction methods have different measurement results: Left hippocampal volume measured by MRI Raw volume method is negatively correlated with MCI and AD (OR [odds ratio] = 0.58, 95%CI [confidence interval]: 0.42, 0.75) right hippocampal volume measured was not associated with MCI OR AD (OR = 0.87, 95%CI: 0.56, 1.18); left hippocampal volume measured by MRI total intracranial volume (TIV) Correction was not associated with MCI and AD (OR = 0.90, 95%CI: 0.62, 1.19), measured right hippocampal volume was not associated with MCI OR AD (OR = 0.81, 95%CI: 0.49, 1.12); left hippocampal volume measured by MRI TIV Correction was not associated with MCI and AD (OR = 0.90, 95%CI: 0.62, 1.19), measured right hippocampus volume was negatively associated with MCI and AD (OR = 0.49, 95%CI: 0.35, 0.62).

CONCLUSION

The shrinkage of hippocampus volume is closely related to MCI and AD. MRI measurement of hippocampus volume is not only an auxiliary diagnostic tool for MCI and AD, but also a good prognosis assessment tool.

摘要

背景

这是首次进行的荟萃分析，旨在比较磁共振成像（MRI）测量的健康正常受试者、轻度认知障碍（MCI）和阿尔茨海默病（AD）患者的海马体积，并分析海马体积变化与 MCI 和 AD 的关系。

方法

从 PubMed、Embase、万方医学和中国知网数据库中提取 2004 年 1 月至 2006 年 12 月发表的英文文献。采用 Stata/SE 16.0 软件进行统计学分析。

结果

MRI 测量的海马体积越小，认知障碍或 AD 越严重。不同的 MRI 后测量校正方法有不同的测量结果：MRI 原始体积法测量的左侧海马体积与 MCI 和 AD 呈负相关（OR[比值比]=0.58，95%CI[置信区间]：0.42，0.75），右侧海马体积与 MCI 或 AD 无相关性（OR=0.87，95%CI：0.56，1.18）；MRI 总颅内体积（TIV）校正测量的左侧海马体积与 MCI 和 AD 无相关性（OR=0.90，95%CI：0.62，1.19），右侧海马体积与 MCI 或 AD 无相关性（OR=0.81，95%CI：0.49，1.12）；MRI TIV 校正测量的左侧海马体积与 MCI 和 AD 无相关性（OR=0.90，95%CI：0.62，1.19），右侧海马体积与 MCI 和 AD 呈负相关（OR=0.49，95%CI：0.35，0.62）。

结论

海马体积缩小与 MCI 和 AD 密切相关。MRI 测量海马体积不仅是 MCI 和 AD 的辅助诊断工具，也是良好的预后评估工具。

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