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Inflammatory signatures of microglia in hypercortisolemia-related depression.

作者信息

Zhao Yanxiang, Huang Yingying, Deng Zhangyuzi, Cao Ying, Yang Jing

机构信息

State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, 100871, China.

Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China.

出版信息

Cell Insight. 2024 Nov 13;4(2):100222. doi: 10.1016/j.cellin.2024.100222. eCollection 2025 Apr.

DOI:10.1016/j.cellin.2024.100222
PMID:39881712
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11772961/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cb/11772961/29ce55454c3b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cb/11772961/29ce55454c3b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cb/11772961/29ce55454c3b/gr1.jpg

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Inflammatory signatures of microglia in hypercortisolemia-related depression.高皮质醇血症相关抑郁症中,小胶质细胞的炎症特征
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Hypercortisolemia in acute stroke is related to the inflammatory response.急性卒中中的高皮质醇血症与炎症反应有关。
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Hypercortisolemia and hippocampal changes in depression.抑郁症中的高皮质醇血症与海马体变化。
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Hypercortisolemia and depression.高皮质醇血症与抑郁症。
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Enriched environment mitigates depressive behavior by changing the inflammatory activation phenotype of microglia in the hippocampus of depression model rats.丰富环境通过改变抑郁模型大鼠海马小胶质细胞的炎症激活表型来减轻抑郁行为。
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Effect of cortisol on energy expenditure and amino acid metabolism in humans.皮质醇对人体能量消耗和氨基酸代谢的影响。
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本文引用的文献

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Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes.抑郁中细胞类型特异性转录组差异在男性和女性中表现出相似的模式,但涉及不同的细胞类型和基因。
Nat Commun. 2023 May 22;14(1):2912. doi: 10.1038/s41467-023-38530-5.
2
Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression.抑郁症中的小胶质细胞:抑郁症发病机制和治疗中小胶质细胞的概述。
J Neuroinflammation. 2022 Jun 6;19(1):132. doi: 10.1186/s12974-022-02492-0.
3
Modulation of microglial activation by antidepressants.
抗抑郁药对小胶质细胞激活的调节。
J Psychopharmacol. 2022 Feb;36(2):131-150. doi: 10.1177/02698811211069110. Epub 2022 Jan 29.
4
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.人类和小鼠单细胞转录组学揭示阿尔茨海默病中 TREM2 依赖性和 TREM2 非依赖性细胞反应。
Nat Med. 2020 Jan;26(1):131-142. doi: 10.1038/s41591-019-0695-9. Epub 2020 Jan 13.
5
Transcriptional mechanism of IRF8 and PU.1 governs microglial activation in neurodegenerative condition.IRF8 和 PU.1 的转录机制调控神经退行性疾病中的小胶质细胞活化。
Protein Cell. 2019 Feb;10(2):87-103. doi: 10.1007/s13238-018-0599-3. Epub 2018 Nov 27.
6
Major depressive disorder.重度抑郁症。
Nat Rev Dis Primers. 2016 Sep 15;2:16065. doi: 10.1038/nrdp.2016.65.
7
HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition.重度抑郁症中的下丘脑-垂体-肾上腺(HPA)轴:皮质醇、临床症状学和基因变异可预测认知功能。
Mol Psychiatry. 2017 Apr;22(4):527-536. doi: 10.1038/mp.2016.120. Epub 2016 Aug 16.
8
The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation.转录因子 IRF8 激活整合素介导的 TGF-β 信号通路并促进神经炎症。
Immunity. 2014 Feb 20;40(2):187-98. doi: 10.1016/j.immuni.2013.11.022. Epub 2014 Jan 30.
9
IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype.IRF8 是将小胶质细胞转化为反应表型的关键转录因子。
Cell Rep. 2012 Apr 19;1(4):334-340. doi: 10.1016/j.celrep.2012.02.014. Epub 2012 Apr 5.
10
A mouse model of depression induced by repeated corticosterone injections.一种通过反复注射皮质酮诱导的抑郁症小鼠模型。
Eur J Pharmacol. 2008 Feb 26;581(1-2):113-20. doi: 10.1016/j.ejphar.2007.12.005. Epub 2007 Dec 14.