Ricon-Becker Itay, Cole Steve W
Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA.
Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, USA.
Brain Behav Immun Health. 2024 Sep 16;42:100867. doi: 10.1016/j.bbih.2024.100867. eCollection 2024 Dec.
Gold-standard psychotherapies like cognitive-behavioral therapy (CBT) show beneficial effects, but patient responses vary, indicating a need to predict and optimize treatment efficacy. Gene expression analysis may offer insights into the interplay between psychosocial processes and biological factors that impact psychopathology and therapeutic response. This integrative review examines 17 studies that assess gene expression in the context of psychotherapy, highlighting innovative frameworks for incorporating gene expression analysis in diagnosis, predicting treatment response, and monitoring treatment progress. Current evidence points to transcriptional control pathways downstream of the hypothalamic-pituitary-adrenal (HPA)-axis and sympathetic nervous system (SNS) signaling pathways, particularly their effects on immune cells (e.g., pro-inflammatory processes and wound healing), as key areas for future research. Higher-level pathway analyses, whether theory-based or empirically driven, appear to offer the most robust framework for future studies. This review also discusses significant limitations of current literature and proposes directions for future research.
像认知行为疗法（CBT）这样的金标准心理疗法显示出有益效果，但患者的反应各不相同，这表明需要预测并优化治疗效果。基因表达分析可能有助于深入了解心理社会过程与影响精神病理学和治疗反应的生物学因素之间的相互作用。这篇综合综述考察了17项在心理治疗背景下评估基因表达的研究，突出了将基因表达分析纳入诊断、预测治疗反应和监测治疗进展的创新框架。目前的证据表明，下丘脑-垂体-肾上腺（HPA）轴和交感神经系统（SNS）信号通路下游的转录控制途径，特别是它们对免疫细胞的影响（如促炎过程和伤口愈合），是未来研究的关键领域。无论是基于理论还是实证驱动的高级通路分析，似乎都为未来的研究提供了最有力的框架。本综述还讨论了当前文献的重大局限性，并提出了未来研究的方向。
