Tian Yanjun, Chen Ruijiao, Jiang Yunlu, Bai Bo, Yang Tongju, Liu Haiqing
Collaborative Innovation Center for Birth Defect Research and Transformation of Shandong Province, Jining Medical University, Jining, China.
School of Mental Health, Jining Medical University, Jining, China.
Front Neurol. 2020 Mar 3;11:75. doi: 10.3389/fneur.2020.00075. eCollection 2020.
The orphan receptor APJ and its endogenous ligand apelin, which are expressed in the brain, are the major components of the apelin/APJ system. Growing evidence shows that the apelin/APJ system plays a vital role in the pathophysiology of cerebral ischemic injury. Targeting the apelin/APJ system may have protective effects on cerebral ischemic injury. In this review, we sum up the latest research progress relating to the actions and therapeutic potential of the apelin/APJ system in ischemic stroke. An in-depth knowledge of the pathophysiological effects of the apelin/APJ system and the underlying mechanisms will help to develop novel therapeutic interventions for ischemic stroke.
孤儿受体APJ及其内源性配体apelin在大脑中表达，它们是apelin/APJ系统的主要组成部分。越来越多的证据表明，apelin/APJ系统在脑缺血损伤的病理生理学中起着至关重要的作用。针对apelin/APJ系统可能对脑缺血损伤具有保护作用。在本综述中，我们总结了apelin/APJ系统在缺血性卒中中的作用和治疗潜力的最新研究进展。深入了解apelin/APJ系统的病理生理效应及其潜在机制将有助于开发针对缺血性卒中的新型治疗干预措施。
