Lin Linsun, Guo Ziyi, Ren Zhuoyu, Feng Yanchen, Fang Peigang, Wang Tao, Chen Min
Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, Macao SAR, China.
Huizhou Health Sciences Polytechnic, Huizhou, China.
Front Cell Neurosci. 2025 Jan 15;18:1521398. doi: 10.3389/fncel.2024.1521398. eCollection 2024.
Depression is a mental disorder that significantly impairs both physical and mental health. Recent studies have shown that reactive astrogliosis have gained significant attention for their involvement in the pathophysiology of depression. However, there is no bibliometric analysis in this research field. This study aims to provide a comprehensive overview of the knowledge structure and research hotspots regarding the role of astrocytes in the mechanisms and treatment of depression through bibliometric analysis. The scope of the literature review encompasses both basic and clinical research.
Publications related to astrocytes in depression and treatment from 2014 to 2023 were searched in the Web of Science Core Collection (WoSCC) database. VOSviewer, CiteSpace, and the R package "bibliometrix" were used to conduct this bibliometric analysis.
From 2014 to 2023, a total of 1,502 documents from 78 countries on astrocytes in depression and treatment were analyzed from 169 journals, with the most co-cited journals being the Journal of Neuroscience and PNAS. China Medical University was the most productive institution. The analysis identified key authors like Verkhratsky Alexei and Baoman Li, and major co-cited references by Rajkowska and Liddelow. Keywords such as "synaptic plasticity," "astrocytes," and "neuroinflammation" revealed research trends focusing on molecular mechanisms, gut microbiota, and inflammation.
This is the first bibliometric study to comprehensively summarize the research trends and advancements regarding astrocytes in depression and its treatment. Through this bibliometric analysis, we aim to enhance the understanding of the significance of astrocytes in depression research and provide new perspectives and insights for future investigations. We hope that this study will facilitate a broader integration of basic and clinical research, offering novel approaches for the treatment of depression.
抑郁症是一种严重损害身心健康的精神障碍。最近的研究表明，反应性星形胶质细胞增生因其参与抑郁症的病理生理学而受到广泛关注。然而，该研究领域尚无文献计量分析。本研究旨在通过文献计量分析全面概述星形胶质细胞在抑郁症机制和治疗中的作用的知识结构和研究热点。文献综述的范围涵盖基础研究和临床研究。
在科学网核心合集（WoSCC）数据库中检索2014年至2023年与抑郁症及治疗中星形胶质细胞相关的出版物。使用VOSviewer、CiteSpace和R包“bibliometrix”进行文献计量分析。
2014年至2023年，共分析了来自78个国家169种期刊的1502篇关于抑郁症及治疗中星形胶质细胞的文献，被引频次最高的期刊是《神经科学杂志》和《美国国家科学院院刊》。中国医科大学是发文量最多的机构。分析确定了关键作者，如Verkhratsky Alexei和李葆明，以及Rajkowska和Liddelow的主要共被引参考文献。“突触可塑性”“星形胶质细胞”和“神经炎症”等关键词揭示了聚焦于分子机制、肠道微生物群和炎症的研究趋势。
这是第一项全面总结抑郁症及其治疗中星形胶质细胞研究趋势和进展的文献计量研究。通过这项文献计量分析，我们旨在加深对星形胶质细胞在抑郁症研究中的重要性的理解，并为未来的研究提供新的视角和见解。我们希望这项研究将促进基础研究和临床研究的更广泛整合，为抑郁症的治疗提供新方法。
