Pan Shu-Man, Li Zhe, Zhou Jing-Qi, Shang Xiang, Gu Tian-Jia, Sun Xiao-Ming, Zhu Zhen-Hua
Affiliated Guangji Hospital of Soochow University, Suzhou 215137, Jiangsu Province, P.R. China.
Curr Neuropharmacol. 2025 Mar 18. doi: 10.2174/011570159X353752250227113751.
Astrocytes have emerged as key players in the pathogenesis of depression and antidepressant treatment. However, comprehensive reviews in this field were absent. The bibliometric analysis can effectively illustrate research trends and hotspots of a specific domain through analysis of publications.
We conducted a bibliometric analysis to overview the current hotspots and research trends of astrocytes in depression and antidepressant treatment.
We collected publications' data from the science citation index expanded (SCI-E) of the Web of Science (WOS) database, and bibliometric analysis was applied through CiteSpace and VOSviewer software. Results were mapped via GraphPad Prism, Adobe Photoshop, and R software.
After analysis of 2896 publications, we analyzed the content of publications, most influential publications, productive journals, most cited journals, core authors, productive countries/regions, and institutions in this field. The cooperation of main countries and organizations was mapped. Most importantly, after a thorough analysis of keywords, we found neuroinflammation is a hot topic in this research field.
The results of the bibliometric study prove neuroinflammation is a hot topic in this research field. Nowadays, many studies have investigated the role of astrocytes in depression and antidepressant treatment from the perspective of neuroinflammation. It is essential to pay more attention to elucidating the mechanisms of astrocyte-mediated neuroinflammation to identify potential targets for antidepressant development.
星形胶质细胞已成为抑郁症发病机制和抗抑郁治疗中的关键因素。然而，该领域缺乏全面的综述。文献计量分析可以通过对出版物的分析有效地阐明特定领域的研究趋势和热点。
我们进行了文献计量分析，以概述星形胶质细胞在抑郁症和抗抑郁治疗方面的当前热点和研究趋势。
我们从Web of Science（WOS）数据库的科学引文索引扩展版（SCI-E）中收集出版物数据，并通过CiteSpace和VOSviewer软件进行文献计量分析。结果通过GraphPad Prism、Adobe Photoshop和R软件进行绘制。
在分析了2896篇出版物后，我们分析了该领域出版物的内容、最具影响力的出版物、高产期刊、被引频次最高的期刊、核心作者、高产国家/地区和机构。绘制了主要国家和组织的合作情况。最重要的是，在对关键词进行深入分析后，我们发现神经炎症是该研究领域的一个热点话题。
文献计量研究结果证明神经炎症是该研究领域的一个热点话题。如今，许多研究已从神经炎症的角度探讨了星形胶质细胞在抑郁症和抗抑郁治疗中的作用。必须更加重视阐明星形胶质细胞介导的神经炎症机制，以确定抗抑郁药物开发的潜在靶点。
