美国大学橄榄球运动员位置与功能连接改变的关联：一项功能磁共振成像研究
Association of player position and functional connectivity alterations in collegiate American football players: an fMRI study.
作者信息
Griffith Owen, Bai Xiaoxiao, Walter Alexa E, Gay Michael, Kelly Jon, Sebastianelli Wayne, Papa Linda, Slobounov Semyon
机构信息
Department of Kinesiology, Penn State University, 19 Recreation Building, University Park, PA, United States.
Social, Life, and Engineering Sciences Imaging Center, Social Science Research Institute, Penn State University, 120F Chandlee Laboratory, University Park, University Park, PA, United States.
出版信息
Front Neurol. 2025 Jan 7;15:1511915. doi: 10.3389/fneur.2024.1511915. eCollection 2024.
INTRODUCTION
Resting state-fMRI, provides a sensitive method for detecting changes in brain functional integrity, both with respect to regional oxygenated blood flow and whole network connectivity. The primary goal of this report was to examine alterations in functional connectivity in collegiate American football players after a season of repetitive head impact exposure.
METHODS
Collegiate football players completed a rs-fMRI at pre-season and 1 week into post-season. A seed-based functional connectivity method, isolating the posterior cingulate cortex (PCC), was utilized to create individual functional connectivity maps. During group analysis, first, voxel-wise paired sample t-tests identified significant changes in connectivity from pre- to post-season, by player, and previous concussion history. Second, 10 DMN ROIs were constructed by overlaying an anatomical map over regions of positive correlation from one-sample t-tests of pre-season and post-season. These ROIs, plus the LpCun, were included in linear mix-effect modeling, with position or concussion history as covariates.
RESULTS
66 players were included (mean age 20.6 years; 100% male; 34 (51.5%) non-speed position players). The 10 DMN ROIs showed no alterations from pre-season to post-season. By concussion history, the right temporal ROI demonstrated a significant effect on baseline functional connectivity ( = 0.03). Speed players, but not non-speed players, demonstrated a significant decrease in functional connectivity in the precuneus from pre- to post-season ( < 0.001).
DISCUSSION
There are region-specific differences functional connectivity related to both position and concussion history in American collegiate football players. Player position affected functional connectivity across a season of football. Position-specific differences in head impact exposure rate and magnitude plays a crucial role in functional connectivity alterations.
引言
静息态功能磁共振成像为检测大脑功能完整性变化提供了一种灵敏的方法，该变化涉及局部氧合血流和全网络连通性。本报告的主要目的是研究美国大学橄榄球运动员在一个赛季反复头部撞击暴露后的功能连通性改变。
方法
大学橄榄球运动员在赛季前和赛季后1周完成静息态功能磁共振成像。采用基于种子点的功能连通性方法，分离后扣带回皮质（PCC），以创建个体功能连通性图谱。在组分析中，首先，通过体素配对样本t检验确定从赛季前到赛季后、按球员以及既往脑震荡史的连通性显著变化。其次，通过将解剖图谱叠加到赛季前和赛季后单样本t检验的正相关区域上构建10个默认模式网络（DMN）感兴趣区（ROI）。这些ROI加上左楔叶被纳入线性混合效应模型，以位置或脑震荡史作为协变量。
结果
纳入66名球员（平均年龄20.6岁；100%为男性；34名（51.5%）非速度位置球员）。10个DMN ROI从赛季前到赛季后未显示出改变。按脑震荡史分析，右侧颞叶ROI对基线功能连通性有显著影响（P = 0.03）。速度型球员而非非速度型球员在赛季前到赛季后楔前叶的功能连通性显著降低（P < 0.001）。
讨论
美国大学橄榄球运动员的功能连通性存在与位置和脑震荡史相关的区域特异性差异。球员位置在一个赛季的橄榄球运动中影响功能连通性。头部撞击暴露率和强度的位置特异性差异在功能连通性改变中起关键作用。
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