Buch Assaf, Eldor Roy, Kis Ofer, Ben-Yehuda Arie, Green Gizell, Greenman Yona, Barak Sharon
Department of Nutritional Sciences, School of Health Sciences, Ariel University, Ariel, Israel.
Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel.
Heliyon. 2025 Jan 2;11(2):e41593. doi: 10.1016/j.heliyon.2024.e41593. eCollection 2025 Jan 30.
This study evaluated the effects of circuit resistance training (CRT), a vegetarian/Mediterranean diet (VegMedD), and empagliflozin on Resting Metabolic Rate (RMR) in older adults with Type 2 Diabetes (T2DM).
67 participants from CEV-65 trial (≥65 years, 61 % female) were randomly assigned to CRT, VegMedD, or empagliflozin for 10 weeks. Assessments included RMR, medical, metabolic, nutritional, anthropometric and functional measurements. RMR changes were analyzed using paired t-tests, effect sizes, and repeated analysis of variance.
No significant RMR differences were found between groups at baseline and post-intervention with minor RMR increases in 16 (CRT) to 25 % (VegMeD/empagliflozin). Factors correlating with RMR changes included sleep hours (r = 0.25), fat percentage (r = -0.27), leg strength (r = 0.29), and systolic blood pressure (r = 0.24). Except for blood pressure, all the other variables predicted RMR changes ( = 0.22).
CRT, VegMedD, and empagliflozin showed similar effects on RMR in elderly with T2DM. Factors predicting changes in RMR are sleep hours, fat percentage, and leg strength, with those who increased/did not change their RMR presenting greater improvement in the aforementioned variables. These findings highlight the potential of these factors as therapeutic targets for improving metabolic health and warrant further investigation.
本研究评估了循环抗阻训练（CRT）、素食/地中海饮食（VegMedD）和恩格列净对2型糖尿病（T2DM）老年患者静息代谢率（RMR）的影响。
来自CEV - 65试验的67名参与者（≥65岁，61%为女性）被随机分配至CRT组、VegMedD组或恩格列净组，为期10周。评估内容包括RMR、医学、代谢、营养、人体测量和功能指标。使用配对t检验、效应量和重复方差分析来分析RMR的变化。
在基线和干预后，各组之间未发现显著的RMR差异，16%（CRT）至25%（VegMeD/恩格列净）的参与者RMR略有增加。与RMR变化相关的因素包括睡眠时间（r = 0.25）、脂肪百分比（r = -0.27）、腿部力量（r = 0.29）和收缩压（r = 0.24）。除血压外，所有其他变量均能预测RMR的变化（r = 0.22）。
CRT、VegMedD和恩格列净对T2DM老年患者的RMR显示出相似的影响。预测RMR变化的因素是睡眠时间、脂肪百分比和腿部力量，RMR增加/未改变的患者在上述变量方面有更大改善。这些发现凸显了这些因素作为改善代谢健康治疗靶点的潜力，值得进一步研究。
