2型糖尿病患者的静息代谢率不会因不同类型的训练而改变。
Resting Metabolic Rate Does Not Change in Response to Different Types of Training in Subjects with Type 2 Diabetes.
作者信息
Karstoft Kristian, Brinkløv Cecilie Fau, Thorsen Ida Kær, Nielsen Jens Steen, Ried-Larsen Mathias
机构信息
Centre of Inflammation and Metabolism, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
出版信息
Front Endocrinol (Lausanne). 2017 Jun 13;8:132. doi: 10.3389/fendo.2017.00132. eCollection 2017.
BACKGROUND AND OBJECTIVES
Ambiguous results have been reported regarding the effects of training on resting metabolic rate (RMR), and the importance of training type and intensity is unclear. Moreover, studies in subjects with type 2 diabetes (T2D) are sparse. In this study, we evaluated the effects of interval and continuous training on RMR in subjects with T2D. Furthermore, we explored the determinants for training-induced alterations in RMR.
METHODS
Data from two studies, both including T2D subjects, were encompassed in this manuscript. Study 1 was a randomized, crossover study where subjects ( = 14) completed three, 2-week interventions [control, continuous walking training (CWT), interval-walking training (IWT)] separated by washout periods. Training included 10 supervised treadmill sessions, 60 min/session. CWT was performed at moderate walking speed [aiming for 73% of walking peak oxygen uptake (VOpeak)], while IWT was performed as alternating 3-min repetitions at slow (54% VOpeak) and fast (89% VOpeak) walking speed. Study 2 was a single-arm training intervention study where subjects ( = 23) were prescribed 12 weeks of free-living IWT (at least 3 sessions/week, 30 min/session). Before and after interventions, RMR, physical fitness, body composition, and glycemic control parameters were assessed.
RESULTS
No overall intervention-induced changes in RMR were seen across the studies, but considerable inter-individual differences in RMR changes were seen in Study 2. At baseline, total body mass (TBM), fat-free mass (FFM), and fat mass were all associated with RMR. Changes in RMR were associated with changes in TBM and fat mass, and subjects who decreased body mass and fat mass also decreased their RMR. No associations were seen between changes in physical fitness, glycemic control, or FFM and changes in RMR.
CONCLUSION
Neither short-term continuous or interval-type training, nor longer term interval training affects RMR in subjects with T2D when no overall changes in body composition are seen. If training occurs concomitant with a reduction in fat mass, however, RMR is decreased.
CLINICAL TRIALS REGISTRATION WWWCLINICALTRIALSGOV
NCT02320526 and NCT02089477.
背景与目的
关于训练对静息代谢率（RMR）的影响，已有一些模棱两可的研究结果报道，且训练类型和强度的重要性尚不清楚。此外，针对2型糖尿病（T2D）患者的研究较少。在本研究中，我们评估了间歇训练和持续训练对T2D患者RMR的影响。此外，我们还探究了训练引起的RMR变化的决定因素。
方法
本研究纳入了两项均包含T2D患者的研究数据。研究1是一项随机交叉研究，受试者（n = 14）完成了三个为期2周的干预阶段[对照、持续步行训练（CWT）、间歇步行训练（IWT）]，各阶段之间有洗脱期。训练包括10次有监督的跑步机训练，每次60分钟。CWT以中等步行速度进行[目标是达到步行峰值摄氧量（VOpeak）的73%]，而IWT则以慢（54% VOpeak）快（89% VOpeak）交替的3分钟重复进行。研究2是一项单臂训练干预研究，受试者（n = 23）接受了为期12周的自由生活IWT训练（每周至少3次，每次30分钟）。在干预前后，评估了RMR、身体素质、身体成分和血糖控制参数。
结果
在这些研究中，未观察到干预引起的RMR总体变化，但在研究2中观察到RMR变化存在显著的个体差异。在基线时，总体质量（TBM）、去脂体重（FFM）和脂肪量均与RMR相关。RMR的变化与TBM和脂肪量的变化相关，体重和脂肪量下降的受试者其RMR也下降。未观察到身体素质、血糖控制或FFM的变化与RMR的变化之间存在关联。
结论
当身体成分无总体变化时，短期的持续训练或间歇训练，以及长期的间歇训练均不会影响T2D患者的RMR。然而，如果训练伴随着脂肪量的减少，RMR则会降低。
临床试验注册
WWWCLINICALTRIALSGOV：NCT02320526和NCT02089477。
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