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肉毒杆菌所致上睑下垂的解剖学、病因学、治疗及法医学意义

Anatomy, Etiology, Management, and Medico-Legal Implications of Botulinum-induced Blepharoptosis.

作者信息

Nittari Giulio, Savva Demetris, Gibelli Filippo, Vulcanescu Diana, De Leo Domenico, Ricci Giovanna

机构信息

Telemedicine and Telepharmacy Centre, School of Medicinal and Health Products Sciences, University of Camerino, Camerino, 62032, Italy.

Plastic, Reconstructive and Aesthetic Surgery, Nicosia General Hospital, Nicosia, 2031, Cyprus.

出版信息

Curr Rev Clin Exp Pharmacol. 2025;20(1):32-37. doi: 10.2174/0127724328310459240809073519.

Abstract

Botulinum toxin injections, a popular aesthetic treatment, have over 7.4 million beneficiaries in the U.S. Despite their safety record, these injections pose potential complications. It is essential for aesthetic practitioners to manage these complications with the least impact on the patient. Upper eyelid ptosis, though rare, is a significant side effect of botulinum toxin injections. Through our study, we have identified the etiology, anatomy, and therapeutic management of botulinum- induced blepharoptosis. Hence, the goal of this study was to identify the basic aetiology of blepharoptosis and manage this complication, as well as discuss the basis of medico-legal implications involving this popular drug. The complex medico-legal implications of botulinum toxin-induced blepharoptosis call for continuous discourse, education, and clarity on drug-use legal standards. With evolving global and Italian legislation, practitioners must ensure they meet care standards, weighing treatment benefits against potential legal and ethical outcomes. Blepharoptosis is a rare but significant complication of botulinum-type injections. Etiology and thorough anatomy are crucial for avoiding this complication and handling it with the least impact on the patient. Medico-legal implications are currently not fully established, but the basis of aesthetic treatment standards, as well as continuing medical education, will ensure correct medico-legal coverage of such complications.

摘要

肉毒杆菌毒素注射是一种广受欢迎的美容治疗方法,在美国有超过740万受益者。尽管其有安全记录,但这些注射仍存在潜在并发症。对于美容从业者来说,以对患者影响最小的方式处理这些并发症至关重要。上睑下垂虽然罕见,但却是肉毒杆菌毒素注射的一种严重副作用。通过我们的研究,我们已经确定了肉毒杆菌毒素引起的上睑下垂的病因、解剖结构和治疗方法。因此,本研究的目的是确定上睑下垂的基本病因并处理这一并发症,同时讨论涉及这种常用药物的医学法律问题的依据。肉毒杆菌毒素引起的上睑下垂复杂的医学法律问题需要持续的讨论、教育以及明确药物使用的法律标准。随着全球和意大利立法的不断发展,从业者必须确保他们符合护理标准,权衡治疗益处与潜在的法律和伦理后果。上睑下垂是肉毒杆菌毒素注射罕见但严重的并发症。病因和详尽的解剖结构对于避免这一并发症并以对患者影响最小的方式处理它至关重要。医学法律问题目前尚未完全明确,但美容治疗标准的依据以及继续医学教育将确保对此类并发症有正确的医学法律覆盖。

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