Aguilar-Parada E, González-Angulo A, del Peón L, Mravko E
Hum Pathol. 1985 May;16(5):511-6. doi: 10.1016/s0046-8177(85)80090-3.
The cytoplasmic membranes of chief cells in parathyroid adenomas from patients with primary hyperparathyroidism associated with either severe or mild hypercalcemia were examined in an attempt to correlate ultrastructural changes and biochemical findings. In the case involving the highest serum calcium level (17.5 mg/dl), the cytoplasmic membrane exhibited numerous long cytoplasmic processes (microvilli) that extended into wide intercellular spaces. In this respect this tumor, associated with severe hypercalcemia, was different from previously described parathyroid adenomas and from the adenomas of the present study that were associated with mild hypercalcemia (12.4 +/- 0.5 mg/dl); the active chief cells of the latter were characterized by a relatively straight plasmalemma with interdigitations and narrow intercellular spaces. Also of interest in the case involving severe hypercalcemia was the presence of numerous nuclear pores and annulate lamellae as well as an inconspicuous Golgi apparatus. These ultrastructural features would seem to indicate the existence of further morphologic parameters for the evaluation of chief cell activity.
对原发性甲状旁腺功能亢进症伴重度或轻度高钙血症患者甲状旁腺腺瘤主细胞的细胞质膜进行了检查，试图将超微结构变化与生化结果相关联。在血清钙水平最高（17.5mg/dl）的病例中，细胞质膜呈现出许多延伸至宽阔细胞间隙的长细胞质突起（微绒毛）。在这方面，与重度高钙血症相关的该肿瘤不同于先前描述的甲状旁腺腺瘤以及本研究中与轻度高钙血症（12.4±0.5mg/dl）相关的腺瘤；后者的活跃主细胞特征为质膜相对平直且有指状交叉以及狭窄的细胞间隙。在重度高钙血症病例中同样有趣的是存在大量核孔和环层板以及不明显的高尔基体。这些超微结构特征似乎表明存在用于评估主细胞活性的进一步形态学参数。
