Dang Jing, Yu Xinlu, Zhang Mengyuan, Dang Liuyi, Li Zheng, Shu Jian
School of Medicine, Faculty of Life Science & Medicine, Northwest University, Xi'an, China.
Laboratory for Functional Glycomics, Faculty of Life Science & Medicine, Northwest University, Xi'an, China.
World J Microbiol Biotechnol. 2025 Jan 30;41(2):55. doi: 10.1007/s11274-025-04272-3.
Carbapenems are a class of β-lactam antibacterial drugs with a broad antibacterial spectrum and strong activity, commonly used to treat serious bacterial infections. However, improper or excessive use of carbapenems can lead to increased bacterial resistance, which is a significant concern as they are often used as last resort for treating multidrug-resistant (MDR) gram-negative bacteria. Confronted with this challenge, it is crucial to comprehensively understand the mechanism of carbapenem resistance to develop effective therapeutic strategies and innovative drugs. In recent years, emerging research on the glycosylation of bacterial proteins has highlighted the crucial role of glycans in various bacterial processes, including carbapenem resistance. Given the limited understanding of bacterial glycosylation, its role in in carbapenem resistance may be more pivotal than currently acknowledged. In this review, we summarize the direct and multifunctional role of glycosylation in bacterial resistance as well as the classical and recently reported mechanisms of bacterial carbapenem resistance, focusing on illuminating the potential role of glycosylation in carbapenem resistance. We also discuss the potential of leveraging this knowledge to develop more effective strategies for combating clinically resistant bacteria.
碳青霉烯类是一类抗菌谱广、活性强的β-内酰胺类抗菌药物，常用于治疗严重细菌感染。然而，碳青霉烯类药物使用不当或过度使用会导致细菌耐药性增加，由于它们常被用作治疗多重耐药（MDR）革兰氏阴性菌的最后手段，这是一个重大问题。面对这一挑战，全面了解碳青霉烯类耐药机制对于制定有效的治疗策略和开发创新药物至关重要。近年来，关于细菌蛋白糖基化的新兴研究突出了聚糖在各种细菌过程中的关键作用，包括碳青霉烯类耐药。鉴于对细菌糖基化的了解有限，其在碳青霉烯类耐药中的作用可能比目前所认识的更为关键。在这篇综述中，我们总结了糖基化在细菌耐药中的直接和多功能作用，以及细菌碳青霉烯类耐药的经典和最近报道的机制，重点阐述糖基化在碳青霉烯类耐药中的潜在作用。我们还讨论了利用这些知识开发更有效策略来对抗临床耐药菌的潜力。
