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古代基因组学与家羊的起源、扩散和发展

Ancient genomics and the origin, dispersal, and development of domestic sheep.

作者信息

Daly Kevin G, Mullin Victoria E, Hare Andrew J, Halpin Áine, Mattiangeli Valeria, Teasdale Matthew D, Rossi Conor, Geiger Sheila, Krebs Stefan, Medugorac Ivica, Sandoval-Castellanos Edson, Özbaşaran Mihriban, Duru Güneş, Gülcür Sevil, Pöllath Nadja, Collins Matthew, Frantz Laurent, Vila Emmanuelle, Zidarov Peter, Stoddart Simon, Boldgiv Bazartseren, Orlando Ludovic, Pearson Mike Parker, Mullville Jacqui, Askeyev Igor V, Askeyev Arthur O, Askeyev Oleg V, Shaymuratova Dilyara N, Van den Hurk Youri, Zeeb-Lanz Andrea, Arbogast Rose-Marie, Hemmer Helmut, Davoudi Hossein, Amiri Sarieh, Doost Sanaz Beizaee, Decruyenaere Delphine, Fathi Homa, Khazaeli Roya, Hassanzadeh Yousef, Sardari Alireza, Lhuillier Johanna, Abdolahi Mostafa, Summers Geoffrey D, Marro Catherine, Bahshaliyev Veli, Berthon Rémi, Çakirlar Canan, Benecke Norbert, Scheu Amelie, Burger Joachim, Sauer Eberhard, Horwitz Liora Kolska, Arbuckle Benjamin, Buitenhuis Hijlke, Gourichon Lionel, Bulatović Jelena, O'Connor Terry, Orton David, Jalabadze Mindia, Rhodes Stephen, Chazan Michael, Özkaya Vecihi, Zeder Melinda, Atıcı Levent, Mashkour Marjan, Peters Joris, Bradley Daniel G

机构信息

Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.

UCD School of Agricultural and Food Science, University College Dublin, Belfield, Ireland.

出版信息

Science. 2025 Jan 31;387(6733):492-497. doi: 10.1126/science.adn2094. Epub 2025 Jan 30.

Abstract

The origins and prehistory of domestic sheep () are incompletely understood; to address this, we generated data from 118 ancient genomes spanning 12,000 years sampled from across Eurasia. Genomes from Central Türkiye ~8000 BCE are genetically proximal to the domestic origins of sheep but do not fully explain the ancestry of later populations, suggesting a mosaic of wild ancestries. Genomic signatures indicate selection by ancient herders for pigmentation patterns, hornedness, and growth rate. Although the first European sheep flocks derive from Türkiye, in a notable parallel with ancient human genome discoveries, we detected a major influx of Western steppe-related ancestry in the Bronze Age.

摘要

家羊()的起源和史前史尚未完全明晰;为解决这一问题,我们从欧亚大陆各地采集了跨越12000年的118个古代基因组数据。公元前约8000年土耳其中部地区的基因组在遗传上与家羊的起源相近,但并不能完全解释后来种群的祖先情况,这表明存在野生祖先的混合情况。基因组特征表明古代牧民对毛色模式、有无角和生长速度进行了选择。尽管第一批欧洲羊群源自土耳其,但与古代人类基因组的发现形成显著平行的是,我们在青铜时代检测到了大量来自西部草原相关的祖先基因流入。

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