Comparative study on renal accumulation of aminoglycoside antibiotics.

Antibiotic activities in the subcellular fractions of rat kidney were determined after a single intraperitoneal injection of streptomycin, gentamicin and amikacin in the doses of 100 mg/kg of body weight. The concentration in the sediment fraction, which consisted mainly of lysosome and mitochondria, is a valuable index for renal accumulation and subsequent toxicity. Half-lives of the aminoglycosides in this fraction were in the order of amikacin (2.34 h), streptomycin (5.86 h), and gentamicin (9.26 h).