阿尔法波和高贝塔波丘脑底核间歇性活动与帕金森病步态冻结严重程度相关。
Alpha and high beta subthalamic intermittent activity correlates with freezing of gait severity in Parkinson's disease.
作者信息
Neto Arnaldo Fim, Godinho Fabio, da Silva Luiz Ricardo Trajano, de Luccas Julia Baldi, Takahata André Kazuo, Figueiredo Eberval Gadelha, Carlotti Junior Carlos Gilberto, Rocha Maria Sheila Guimarães, Soriano Diogo Coutinho
机构信息
Center of Engineering, Modeling and Applied Social Sciences, Federal University of ABC (UFABC), São Bernardo do Campo, Brazil; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, São Paulo, Brazil; Samsung R&D Institute Brazil (SRBR), Campinas, São Paulo, Brazil.
Center of Engineering, Modeling and Applied Social Sciences, Federal University of ABC (UFABC), São Bernardo do Campo, Brazil; Department of Functional Neurosurgery, Santa Marcelina Hospital, São Paulo, São Paulo, Brazil; Division of Neurosurgery, Department of Neurology, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil.
出版信息
Clin Neurophysiol. 2025 Mar;171:51-60. doi: 10.1016/j.clinph.2025.01.005. Epub 2025 Jan 27.
INTRODUCTION
Freezing of gait (FOG) is a disabling symptom that affects over half of Parkinson's disease patients (PD) and hinders the ability to walk. Subthalamic nucleus (STN) deep brain stimulation (DBS) effectiveness in ameliorating the FOG remains controversial, lacking a reliable electrophysiological biomarker from local field potentials (LFP).
METHODS
The LFP-STN rhythms bandpower and dynamics were characterized at rest across groups in a cohort of 23 patients (14 with FOG, and 9 without, n-FOG).
RESULTS
FOG patients presented enhanced alpha bandpower (FOG vs. n-FOG: 0.331 ± 0.087 vs. 0.248 ± 0.089; p = 0.011) and intermittent (burst) alpha amplitude (FOG vs. n-FOG: 0.610 ± 0.068 vs. 0.524 ± 0.086; p = 0.005). Both intermittent alpha (r = 0.330, p = 0.046) and intermittent high beta amplitude (r = 0.415, p = 0.011) correlated with the FOG score. Alpha burst amplitude correlated with FOG severity (r = 0.479, p = 0.003), and high beta burst amplitude inversely correlated (r = -0.411, p = 0.014) with the performance-oriented mobility assessment (POMA) index.
CONCLUSION
These results suggest that alpha and high beta subthalamic oscillations impact FOG symptoms.
SIGNIFICANCE
The investigation suggests potentially newer co-biomarkers of FOG to guide multi-rhythm paradigms in DBS treatment.
引言
冻结步态（FOG）是一种致残症状，影响超过半数的帕金森病（PD）患者，并妨碍行走能力。丘脑底核（STN）深部脑刺激（DBS）改善FOG的有效性仍存在争议，缺乏来自局部场电位（LFP）的可靠电生理生物标志物。
方法
对23例患者（14例有FOG，9例无FOG，即非FOG组）进行静息状态下LFP-STN节律的带功率和动力学特征分析。
结果
FOG患者表现出增强的α带功率（FOG组与非FOG组：0.331±0.087 vs. 0.248±0.089；p = 0.011）和间歇性（爆发性）α振幅（FOG组与非FOG组：0.610±0.068 vs. 0.524±0.086；p = 0.005）。间歇性α（r = 0.330，p = 0.046）和间歇性高β振幅（r = 0.415，p = 0.011）均与FOG评分相关。α爆发振幅与FOG严重程度相关（r = 0.479，p = 0.003），而高β爆发振幅与以性能为导向的运动评估（POMA）指数呈负相关（r = -0.411，p = 0.014）。
结论
这些结果表明，丘脑底核的α和高β振荡影响FOG症状。
意义
该研究提示了可能用于指导DBS治疗中多节律模式的FOG新的联合生物标志物。
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