Helal Imen, Jouini Raja, Brahim Ehsen Ben, Cherif Mona, Khanchel Fatma, Chadli-Debbiche Aschraf
Faculty of Medicine of Tunis, Tunis El Manar University, Djebal Lakhdar Street, 1006 Tunis, Tunisia; Department of Pathology, Habib Thameur Hospital, 1082 Tunis, Tunisia.
Faculty of Medicine of Tunis, Tunis El Manar University, Djebal Lakhdar Street, 1006 Tunis, Tunisia; Department of Pathology, Habib Thameur Hospital, 1082 Tunis, Tunisia.
Int J Surg Case Rep. 2025 Feb;127:110937. doi: 10.1016/j.ijscr.2025.110937. Epub 2025 Jan 27.
More needs to be understood concerning the natural progression and visual attributes of intracholecystic papillary neoplasm. Its longevity, especially the rate at which it transitions from benign to malignant growths, remains ambiguous. Consequently, it is imperative to elucidate the intrinsic progression of this precancerous lesion in the gallbladder.
A 70-year-old North African woman arrived at the emergency department with abdominal pain, anorexia, and weight loss. The patient's physical examination showed favourable results for abdominal pain, nausea, vomiting, and constipation. A CT scan revealed a heterogeneous fundic tissue mass within the gallbladder, which indicated a cholecystectomy due to clinical manifestations and suspicion of a neoplastic disease. The patient underwent a laparoscopic cholecystectomy, and the removed gallbladder was addressed for pathological analysis, revealing an intracholecystic papillary neoplasm.
Intracholecystic papillary neoplasm (ICPN) is a rare precancerous tumour affecting middle-aged women aged 38 to 83. It is characterized by raised projections of the lining epithelium in the gallbladder cavity, with a prominent mucinous substance. ICPN can be diagnosed using ultrasound, CT scan, and MRI. Treatment usually involves surgical removal of the gallbladder, known as cholecystectomy, and histological analysis to determine the tumour's stage and grade. Early detection is crucial for preventing the progression of ICPN into invasive carcinoma.
Due to the rarity of ICPN, more data are needed to establish more effective diagnostic procedures and screening criteria. The main objective of reporting this case is to increase awareness of this rare and potentially fatal tumour.
关于胆囊内乳头状瘤的自然病程和视觉特征，仍有许多需要了解的地方。其生存期，尤其是从良性生长转变为恶性生长的速率，仍不明确。因此，阐明这种胆囊癌前病变的内在进展情况势在必行。
一名70岁的北非女性因腹痛、厌食和体重减轻来到急诊科。患者的体格检查显示腹痛、恶心、呕吐和便秘的检查结果良好。CT扫描显示胆囊内有一个不均匀的胃底部组织肿块，鉴于临床表现和对肿瘤性疾病的怀疑，建议进行胆囊切除术。患者接受了腹腔镜胆囊切除术，切除的胆囊送去做病理分析，结果显示为胆囊内乳头状瘤。
胆囊内乳头状瘤（ICPN）是一种罕见的癌前肿瘤，影响年龄在38至83岁的中年女性。其特征是胆囊腔内衬上皮有凸起，伴有大量黏液物质。ICPN可通过超声、CT扫描和MRI进行诊断。治疗通常包括手术切除胆囊，即胆囊切除术，并进行组织学分析以确定肿瘤的分期和分级。早期检测对于预防ICPN进展为浸润性癌至关重要。
由于ICPN罕见，需要更多数据来建立更有效的诊断程序和筛查标准。报告该病例的主要目的是提高对这种罕见且可能致命肿瘤的认识。
