Waclawovsky Aline Josiane, Dos Santos Eduarda Bitencourt, de Oliveira Antônio Anderson Ramos, Stubbs Brendon, Schuch Felipe Barreto
Postgraduate Program in Psychiatry and Mental Health, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Postgraduate Program in Movement Sciences and Rehabilitation, Federal University of Santa Maria, Santa Maria, Brazil.
J Affect Disord. 2025 Apr 15;375:297-305. doi: 10.1016/j.jad.2025.01.138. Epub 2025 Jan 28.
The objective of this study is to conduct a literature review and summarize existing research comparing levels of blood markers of endothelial function in people with depression with controls. We searched major databases (Embase, PubMed, Web of Science, and PsycINFO) from inception to 23.07.2023, for studies comparing endothelial function blood markers in people with depression and controls including intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), monocyte chemoattractant protein-1 (MCP-1), and sE-selectin. Comparative random effects meta-analysis, calculating standardized mean differences in levels of sICAM-1, sVCAM-1, MCP-1, and sE-selectin between depressed and controls were conducted. Study protocol was registered with PROSPERO (CRD42020222487). Nineteen studies including 10,566 participants [1322 depressed (mean age = 49.1 years, 63 % females) and 9239 controls (mean age = 52.3 years, 57.5 % females)] were included. People with depression had higher levels of sICAM-1 (SMD = 0.98, 95 % CI: 0.52; 1.44, P < 0.001) and MCP-1 (SMD = 0.37, 95 % CI: 0.01; 0.72, P = 0.04) than controls. There was a small difference on sVCAM-1 (k = 10, SMD = 0.215, 95%CI: 0.013; 0.417, p = 0.04), but no difference in levels of E-selectin between people with depression and controls (k = 5,SMD = 0.21, 95%CI:-0.09;0.52, P = 0.17). Subgroup analyzes demonstrated that people with depression and comorbid chronic illnesses, such as diabetes, have higher levels of sICAM-1 than people with depression without comorbid chronic illness. Mean age moderate the difference in sICAM-1 levels between depressed and controls (SMD = 0.01, 95%CI:-0.05;-0.02,P < 0.001, R = 0.61). Our findings suggest that people with depression exhibit increased levels of endothelial activation markers compared to controls, suggesting an endothelial dysfunction among this population.
本研究的目的是进行文献综述，并总结现有研究，比较抑郁症患者与对照组的内皮功能血液标志物水平。我们检索了主要数据库（Embase、PubMed、Web of Science和PsycINFO），从建库至2023年7月23日，查找比较抑郁症患者与对照组内皮功能血液标志物的研究，包括细胞间黏附分子-1（sICAM-1）、血管细胞黏附分子-1（sVCAM-1）、单核细胞趋化蛋白-1（MCP-1）和sE-选择素。进行了比较随机效应荟萃分析，计算抑郁症患者与对照组之间sICAM-1、sVCAM-1、MCP-1和sE-选择素水平的标准化平均差异。研究方案已在PROSPERO（CRD42020222487）注册。纳入了19项研究，共10566名参与者[1322名抑郁症患者（平均年龄=49.1岁，63%为女性）和9239名对照组（平均年龄=52.3岁，57.5%为女性）]。抑郁症患者的sICAM-1（标准化平均差=0.98，95%置信区间：0.52；1.44，P<0.001）和MCP-1（标准化平均差=0.37，95%置信区间：0.01；0.72，P=0.04）水平高于对照组。sVCAM-1存在微小差异（k=10，标准化平均差=0.215，95%置信区间：0.013；0.417，p=0.04），但抑郁症患者与对照组的E-选择素水平无差异（k=5，标准化平均差=0.21，95%置信区间：-0.09；0.52，P=0.17）。亚组分析表明，患有抑郁症并伴有糖尿病等慢性疾病的患者，其sICAM-1水平高于无慢性疾病合并症的抑郁症患者。平均年龄调节了抑郁症患者与对照组之间sICAM-1水平的差异（标准化平均差=0.01，95%置信区间：-0.05；-0.02，P<0.001，R=0.61）。我们的研究结果表明，与对照组相比，抑郁症患者的内皮激活标志物水平升高，提示该人群存在内皮功能障碍。
