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The emerging role of hyperpolarized Xe MRI in pulmonary hypertension.超极化氙气磁共振成像在肺动脉高压中的新兴作用
Expert Rev Respir Med. 2025 Jul 10:1-5. doi: 10.1080/17476348.2025.2529543.

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1
Noninvasive diagnosis of pulmonary hypertension with hyperpolarised Xe magnetic resonance imaging and spectroscopy.基于超极化氙磁共振成像和波谱分析的肺动脉高压无创诊断
ERJ Open Res. 2022 May 16;8(2). doi: 10.1183/23120541.00035-2022. eCollection 2022 Apr.
2
Inhaled Treprostinil after Initial Clinical Worsening: To Continue or Not to Continue, That's the Question.初始临床病情恶化后吸入用曲前列尼尔：继续还是停止，这是个问题。
Am J Respir Crit Care Med. 2022 May 15;205(10):1250-1251. doi: 10.1164/rccm.202112-2721LE.
3
Reply to Jin .: Inhaled Treprostinil after Initial Clinical Worsening: To Continue or Not to Continue, That's the Question.对金的回复：初始临床病情恶化后吸入曲前列尼尔：继续还是停止，这是个问题。
Am J Respir Crit Care Med. 2022 May 15;205(10):1251-1252. doi: 10.1164/rccm.202201-0081LE.
4
Efficacy of Inhaled Treprostinil on Multiple Disease Progression Events in Patients with Pulmonary Hypertension due to Parenchymal Lung Disease in the INCREASE Trial.INCREASE 试验中吸入曲前列尼尔治疗特发性肺纤维化相关性肺动脉高压患者多疾病进展事件的疗效。
Am J Respir Crit Care Med. 2022 Jan 15;205(2):198-207. doi: 10.1164/rccm.202107-1766OC.
5
Protocols for multi-site trials using hyperpolarized Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the Xe MRI clinical trials consortium.使用超极化氙气磁共振成像进行通气、肺泡气腔大小和气体交换成像的多中心试验方案：氙气磁共振成像临床试验联盟的立场文件
Magn Reson Med. 2021 Dec;86(6):2966-2986. doi: 10.1002/mrm.28985. Epub 2021 Sep 3.
6
Inhaled treprostinil and forced vital capacity in patients with interstitial lung disease and associated pulmonary hypertension: a post-hoc analysis of the INCREASE study.吸入性曲前列尼尔与用力肺活量在间质性肺疾病合并肺动脉高压患者中的相关性：INCREASE 研究的事后分析。
Lancet Respir Med. 2021 Nov;9(11):1266-1274. doi: 10.1016/S2213-2600(21)00165-X. Epub 2021 Jun 29.
7
Using hyperpolarized Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity.利用氙气超极化交换 MRI 对区域性气道、膜和毛细血管对弥散能力的贡献进行建模。
J Appl Physiol (1985). 2021 May 1;130(5):1398-1409. doi: 10.1152/japplphysiol.00702.2020. Epub 2021 Mar 18.
8
Inhaled Treprostinil in Pulmonary Hypertension Due to Interstitial Lung Disease.特发性肺纤维化相关肺动脉高压患者应用吸入曲前列尼尔治疗
N Engl J Med. 2021 Jan 28;384(4):325-334. doi: 10.1056/NEJMoa2008470. Epub 2021 Jan 13.
9
The Trouble With Group 3 Pulmonary Hypertension in Interstitial Lung Disease: Dilemmas in Diagnosis and the Conundrum of Treatment.特发性肺纤维化相关 3 型肺动脉高压的困境：诊断中的两难处境与治疗中的难题。
Chest. 2020 Oct;158(4):1651-1664. doi: 10.1016/j.chest.2020.04.046. Epub 2020 May 7.
10
Diverse cardiopulmonary diseases are associated with distinct xenon magnetic resonance imaging signatures.多种心肺疾病与独特的氙气磁共振成像特征相关。
Eur Respir J. 2019 Dec 12;54(6). doi: 10.1183/13993003.00831-2019. Print 2019 Dec.

Xenon-129 magnetic resonance imaging and spectroscopy detects response to therapy in pulmonary hypertension.

作者信息

Alenezi Fawaz, Costelle Anna, Sharma Prerna, Barrett Megan, Bier Elianna A, Driehuys Bastiaan, Rajagopal Sudarshan

机构信息

Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.

F. Alenezi and A. Costelle contributed equally as first authors.

出版信息

Eur Respir J. 2025 Feb 27;65(2). doi: 10.1183/13993003.01651-2024. Print 2025 Feb.

DOI:10.1183/13993003.01651-2024
PMID:39884765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11890203/
Abstract
摘要