POLARIS, Academic Unit of Radiology, University of Sheffield, Sheffield, UK.
Academic Directorate of Respiratory Medicine, Sheffield Teaching Hospitals Foundation Trust, Sheffield, UK.
Thorax. 2019 May;74(5):500-502. doi: 10.1136/thoraxjnl-2018-211851. Epub 2018 Nov 2.
Prognosticating idiopathic pulmonary fibrosis (IPF) is challenging, in part due to a lack of sensitive biomarkers. A recent article in described how hyperpolarised xenon magnetic resonance spectroscopy may quantify regional gas exchange in IPF lungs. In a population of patients with IPF, we find that the xenon signal from red blood cells diminishes relative to the tissue/plasma signal over a 12-month time period, even when the diffusion factor for carbon monoxide is static over the same time period. We conclude that hyperpolarised Xe MR spectroscopy may be sensitive to short-term changes in interstitial gas diffusion in IPF.
预测特发性肺纤维化（IPF）具有挑战性，部分原因是缺乏敏感的生物标志物。最近在[杂志名称]上的一篇文章描述了超极化氙磁共振波谱如何定量测量 IPF 肺部的区域气体交换。在一组 IPF 患者中，我们发现即使在同一时间段内一氧化碳的扩散系数保持不变，红细胞的氙信号相对于组织/血浆信号也会在 12 个月的时间内逐渐减少。我们得出结论，超极化氙磁共振波谱可能对 IPF 中间质气体扩散的短期变化敏感。
Zotero 插件