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在一名患有结核病免疫重建炎症综合征的晚期艾滋病患者中，皮质类固醇使卡波西肉瘤显现出来。

Kaposi's sarcoma unmasked by corticosteroids in an advanced HIV patient with tuberculosis immune reconstitution inflammatory syndrome.

作者信息

Kadnur Harshith B, Reddy Haripriya Challa, Wanve Balasaheb, Sonowal Rumapriya, Rughwani Hardik, Sekaran Anuradha

机构信息

Department of Infectious Diseases, AIG Hospitals, Gachibowli, Hyderabad, Telangana, India.

Department of Medical Oncology, AIG Hospitals, Gachibowli, Hyderabad, Telangana, India.

出版信息

Indian J Sex Transm Dis AIDS. 2024 Jul-Dec;45(2):141-143. doi: 10.4103/ijstd.ijstd_8_24. Epub 2024 Dec 13.

DOI:10.4103/ijstd.ijstd_8_24
PMID:39886252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11776919/
Abstract

In this case report, we present a 35-year-old homosexual man with advanced HIV disease and disseminated tuberculosis (TB) who developed paradoxical TB immune reconstitution inflammatory syndrome (IRIS). Corticosteroids, vital in life-threatening IRIS, were initiated, resulting in symptom resolution but unmasking AIDS-associated Kaposi's sarcoma (KS). Diagnostic confirmation revealed disseminated KS, necessitating a comprehensive therapeutic strategy involving chemotherapy and thalidomide as a steroid-sparing agent. This case underscores the complexity of managing advanced HIV disease with IRIS, emphasizing the cautious use of corticosteroids due to the potential risk of KS unmasking. The report contributes to the limited documentation of indigenous HIV-associated KS cases in India and highlights the need for vigilant monitoring and careful therapeutic decisions in this population.

摘要

在本病例报告中，我们呈现了一名35岁的同性恋男性，他患有晚期艾滋病和播散性结核病，并发了矛盾性结核免疫重建炎症综合征（IRIS）。对危及生命的IRIS至关重要的皮质类固醇药物开始使用，症状得以缓解，但却使艾滋病相关的卡波西肉瘤（KS）显现出来。诊断证实为播散性KS，这需要采取包括化疗和使用沙利度胺作为类固醇替代药物的综合治疗策略。该病例强调了在伴有IRIS的晚期艾滋病管理中的复杂性，突出了由于存在使KS显现的潜在风险而需谨慎使用皮质类固醇药物。该报告为印度本土艾滋病相关KS病例的有限文献记录做出了贡献，并强调了对该人群进行密切监测和谨慎治疗决策的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20cd/11776919/55761801977b/IJSTD-45-141-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20cd/11776919/294dc6ea7970/IJSTD-45-141-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20cd/11776919/b15095a6bec0/IJSTD-45-141-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20cd/11776919/55761801977b/IJSTD-45-141-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20cd/11776919/294dc6ea7970/IJSTD-45-141-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20cd/11776919/b15095a6bec0/IJSTD-45-141-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20cd/11776919/55761801977b/IJSTD-45-141-g003.jpg

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本文引用的文献

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Epidemiology of Kaposi's Sarcoma.卡波西肉瘤的流行病学
Cancers (Basel). 2021 Nov 14;13(22):5692. doi: 10.3390/cancers13225692.
2
Prednisone for the Prevention of Paradoxical Tuberculosis-Associated IRIS.泼尼松预防结核分枝杆菌潜伏感染相关的矛盾性免疫重建炎症综合征。
N Engl J Med. 2018 Nov 15;379(20):1915-1925. doi: 10.1056/NEJMoa1800762.
3
Global epidemiology of human herpesvirus 8 in men who have sex with men: A systematic review and meta-analysis.全球男男性行为人群中人类疱疹病毒 8 的流行病学：系统评价和荟萃分析。
J Med Virol. 2018 Mar;90(3):582-591. doi: 10.1002/jmv.24960. Epub 2017 Nov 7.
4
Disseminated Kaposi's sarcoma in a human immunodeficiency virus-infected homosexual Indian man.一名感染人类免疫缺陷病毒的印度同性恋男子发生播散性卡波西肉瘤。
Indian J Dermatol Venereol Leprol. 2017 Jan-Feb;83(1):78-83. doi: 10.4103/0378-6323.193612.
5
Steroids are a risk factor for Kaposi's sarcoma-immune reconstitution inflammatory syndrome and mortality in HIV infection.类固醇是卡波西肉瘤免疫重建炎症综合征的一个危险因素，也是HIV感染患者死亡的危险因素。
AIDS. 2016 Mar 27;30(6):909-14. doi: 10.1097/QAD.0000000000000993.
6
Seroprevalence and determinants of Kaposi sarcoma-associated human herpesvirus 8 in Indian HIV-infected males.印度男性HIV感染者中卡波西肉瘤相关人类疱疹病毒8型的血清流行率及其决定因素
AIDS Res Hum Retroviruses. 2014 Dec;30(12):1192-6. doi: 10.1089/aid.2014.0184.
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Human herpes virus-8 infections among subjects with human immunodeficiency virus infection and normal healthy individuals in India.印度人类免疫缺陷病毒感染者和正常健康个体中人类疱疹病毒 8 感染。
Intervirology. 2013;56(4):253-7. doi: 10.1159/000349890. Epub 2013 Jun 11.
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