Zhang Shuyi, Jiao Yao, Liu Siyan, Liu Yitong, Liu Yi
Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, China.
Oral Dis. 2025 Jan 30. doi: 10.1111/odi.15264.
To review the effect of outer membrane vesicles (OMVs) of the periodontal pathogen Porphyromonas gingivalis (P. gingivalis) on macrophages during periodontitis development.
Literature pertaining to P. gingivalis OMVs and macrophages was reviewed and discussed, with a focus on the immunomodulatory effects of P. gingivalis OMVs on macrophages.
P. gingivalis OMVs affect the recognition, phagocytosis, polarization, and apoptosis functions of macrophages. However, information on their antigen-presenting effect remains lacking, and further research is required for clinical applications.
P. gingivalis OMVs can influence the development of periodontitis through immune modulation of macrophages; however, further research is required to provide novel ideas for the prevention and treatment of periodontitis.
探讨牙周病原体牙龈卟啉单胞菌（P. gingivalis）的外膜囊泡（OMVs）在牙周炎发展过程中对巨噬细胞的影响。
回顾并讨论了与牙龈卟啉单胞菌OMVs和巨噬细胞相关的文献，重点关注牙龈卟啉单胞菌OMVs对巨噬细胞的免疫调节作用。
牙龈卟啉单胞菌OMVs影响巨噬细胞的识别、吞噬、极化和凋亡功能。然而，关于其抗原呈递作用的信息仍然缺乏，临床应用还需要进一步研究。
牙龈卟啉单胞菌OMVs可通过对巨噬细胞的免疫调节影响牙周炎的发展；然而，需要进一步研究为牙周炎的预防和治疗提供新思路。
