Gao Xuehan, Peng Xingtong, Wang Rongxi, Qian Zhihong, Zhou Xiaoyun, Zhu Zhaohui, Chen Yeye
Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
J Cell Mol Med. 2025 Feb;29(3):e70248. doi: 10.1111/jcmm.70248.
Mucosa-associated lymphoid tissue (MALT) lymphoma is an extranodal low-grade non-Hodgkin lymphoma that extremely rarely localises to the mediastinum. A 34-year-old female with chronic arthralgia, sicca and rash was found to have a well-demarcated mediastinal cystic mass with equivocal nodular enhancement within the cystic wall on chest CT during a workup for Sjögren's syndrome. Subsequent Ga-Pentixafor-PET/CT revealed focal uptake increase within the cystic capsule. The patient underwent thoracoscopic resection of the mediastinal lesion, and pathology revealed MALT lymphoma in the wall of a thymic cyst. This case highlights that Ga-pentixafor PET/CT could be valuable for the non-invasive detection of occult thymic MALT lymphoma. Trial Registration: ClinicalTrials.gov. (www.clinicaltrials.gov, NCT06086327).
黏膜相关淋巴组织（MALT）淋巴瘤是一种结外低度非霍奇金淋巴瘤，极少定位于纵隔。一名34岁患有慢性关节痛、干燥症状和皮疹的女性，在干燥综合征检查过程中，胸部CT发现一个边界清晰的纵隔囊性肿块，囊壁内有可疑的结节状强化。随后的镓-喷替酸五乙酸（Ga-Pentixafor）PET/CT显示囊壁有局灶性摄取增加。患者接受了纵隔病变的胸腔镜切除术，病理显示胸腺囊肿壁内为MALT淋巴瘤。该病例强调Ga-Pentixafor PET/CT对隐匿性胸腺MALT淋巴瘤的无创检测可能具有重要价值。试验注册：ClinicalTrials.gov。（www.clinicaltrials.gov，NCT06086327）
