Skrzypski Marek, Wojciechowicz Tatiana, Rak Agnieszka, Krążek Małgorzata, Fiedorowicz Joanna, Strowski Mathias Z, Nowak Krzysztof W
J Endocrinol. 2025 Feb 18;265(1). doi: 10.1530/JOE-24-0117. Print 2025 Apr 1.
Adropin, a peptide hormone encoded by the energy homeostasis-associated gene, is expressed in various tissues, including the brain. Accumulating evidence from in vivo and in vitro studies highlights adropin's pivotal role in modulating carbohydrate and lipid metabolism. Notably, circulating adropin levels are lower in overweight and obese humans, and experimental interventions involving adropin overexpression or synthetic administration demonstrate promising outcomes in mitigating obesity-related metabolic abnormalities and preventing weight gain. This review comprehensively summarizes the current understanding of adropin's potential implications in diverse types of diabetes. Specifically, it explores adropin's utility as a biomarker for different types of diabetes and elucidates its significance as a potential predictor of diabetic adverse outcomes. Furthermore, the review delves into the beneficial effects of adropin treatment in animal models of experimentally induced diabetes, shedding light on its mechanisms of action in modulating glucose metabolism. In this comprehensive overview, we aim to provide a nuanced understanding of multifaceted role of adropin in diabetes pathogenesis and its therapeutic potential in combating this global health challenge.
内脂素是一种由能量稳态相关基因编码的肽类激素，在包括大脑在内的各种组织中表达。体内和体外研究积累的证据突显了内脂素在调节碳水化合物和脂质代谢中的关键作用。值得注意的是，超重和肥胖人群的循环内脂素水平较低，涉及内脂素过表达或合成给药的实验干预在减轻肥胖相关代谢异常和预防体重增加方面显示出有前景的结果。本综述全面总结了目前对内脂素在不同类型糖尿病中潜在影响的认识。具体而言，探讨了内脂素作为不同类型糖尿病生物标志物的效用，并阐明了其作为糖尿病不良结局潜在预测指标的意义。此外，该综述深入研究了内脂素治疗在实验性诱导糖尿病动物模型中的有益作用，揭示了其调节葡萄糖代谢的作用机制。在这一全面概述中，我们旨在对内脂素在糖尿病发病机制中的多方面作用及其应对这一全球健康挑战的治疗潜力提供细致入微的理解。
