Carswell Claire, Bramham Kate, Chilcot Joseph, Jacobs Rowena, Osborn David, Siddiqi Najma
Department of Health Sciences, University of York, York, United Kingdom.
King's College Hospital NHS Trust, London, United Kingdom.
PLoS One. 2025 Jan 31;20(1):e0310568. doi: 10.1371/journal.pone.0310568. eCollection 2025.
People with severe mental illness (SMI) are more likely to develop long-term physical health conditions, including type 2 diabetes and cardiovascular disease, compared to people without SMI. This contributes to an inequality in life expectancy known as the 'mortality gap'. Chronic kidney disease (CKD) is a growing global health concern set to be the 5th leading cause of life-years lost by 2040. However, there is limited research exploring the relationship between CKD and SMI. This systematic review will aim to examine the prevalence and incidence of CKD among people with SMI.
We will search Medline, Embase, PsycINFO, CINAHL, Scopus and Web of Science for primary epidemiological research reporting the prevalence or incidence of CKD among people with SMI in any setting. Retrieved records will be managed in Covidence and screened by two independent reviewers. Data will be extracted from included studies using a piloted data extraction form, and the quality of studies will be evaluated using the appropriate JBI Critical Appraisal Checklist. The certainty of evidence will be assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach. Data from the included studies will be narratively synthesised. Meta-analyses will be conducted using random effects models to examine the prevalence and incidence of CKD among people with SMI.
There is limited research exploring the relationship between CKD and SMI, and this proposed systematic review will be the first to examine the prevalence of CKD among people with SMI. This review will highlight the extent of the problem and provide a foundation for future research to improve health outcomes for people with SMI.
与没有严重精神疾病（SMI）的人相比，患有严重精神疾病的人更有可能患上包括2型糖尿病和心血管疾病在内的长期身体健康问题。这导致了预期寿命方面的不平等，即所谓的“死亡率差距”。慢性肾脏病（CKD）是一个日益受到全球关注的健康问题，预计到2040年将成为导致生命年损失的第五大主要原因。然而，探索CKD与SMI之间关系的研究有限。本系统评价旨在研究SMI患者中CKD的患病率和发病率。
我们将在Medline、Embase、PsycINFO、CINAHL、Scopus和Web of Science中检索主要的流行病学研究，这些研究报告了在任何环境下SMI患者中CKD的患病率或发病率。检索到的记录将在Covidence中进行管理，并由两名独立的评审员进行筛选。将使用预先试验的数据提取表从纳入的研究中提取数据，并使用适当的JBI批判性评价清单评估研究质量。将使用推荐分级、评估、制定和评价（GRADE）方法评估证据的确定性。将对纳入研究的数据进行叙述性综合分析。将使用随机效应模型进行荟萃分析，以研究SMI患者中CKD的患病率和发病率。
探索CKD与SMI之间关系的研究有限，而本拟议的系统评价将是首次研究SMI患者中CKD的患病率。本评价将突出问题的严重程度，并为未来改善SMI患者健康结局的研究提供基础。
