Duan Xinyu, Agar Osman Tuncay, Barrow Colin J, Dunshea Frank R, Suleria Hafiz A R
School of Agriculture, Food and Ecosystem Sciences, Faculty of Science, The University of Melbourne, Parkville, Victoria, Australia.
Centre for Sustainable Bioproducts, School of Life and Environmental Sciences, Deakin University, Victoria, Australia.
Crit Rev Food Sci Nutr. 2025;65(5):833-855. doi: 10.1080/10408398.2023.2282669. Epub 2023 Nov 21.
Seaweeds have garnered considerable attention due to their capacity to serve as exceptional reservoirs of numerous bioactive metabolites possessing substantial chemical and biological significance. .Phlorotannins constitute a significant class of natural polyphenols originating from brown seaweeds, featuring a broad spectrum of bioactive attributes and demonstrating potential applicability across various sectors. The potential health advantages associated with phlorotannins, particularly concerning the prevention of conditions linked to oxidative stress, such as inflammation, diabetes, and allergies, have generated substantial interest within the food and pharmaceutical industries. Nevertheless, current research remains insufficient in providing a comprehensive understanding of their absorption, as comparisons drawn with their terrestrial counterparts remain speculative. It is commonly presumed that phenolic compounds, including phlorotannins, face challenges due to their limited solubility, instability, and extensive metabolism, all of which restrict their bioavailability. In order to circumvent these limitations and amplify their utility as components of medicinal formulations or healthcare products, researchers have explored various strategies, including the encapsulation or integration of phlorotannins into nano-/micro-particles or advanced drug delivery systems. This review offers a thorough exploration of the structural and biological attributes of phlorotannins and furnishes insights into potential strategies showing promise for their effective utilization in preclinical and clinical applications.
海藻因其能够作为众多具有重要化学和生物学意义的生物活性代谢物的特殊储存库而备受关注。褐藻多酚是一类源自褐藻的重要天然多酚，具有广泛的生物活性特性，并在各个领域显示出潜在的适用性。与褐藻多酚相关的潜在健康益处，特别是在预防与氧化应激相关的疾病（如炎症、糖尿病和过敏）方面，已在食品和制药行业引起了极大的兴趣。然而，目前的研究在全面了解其吸收方面仍显不足，因为与陆地同类物质的比较仍具有推测性。通常认为，包括褐藻多酚在内的酚类化合物由于其溶解度有限、稳定性差和广泛的代谢作用而面临挑战，所有这些都限制了它们的生物利用度。为了克服这些限制并扩大其作为药物制剂或保健产品成分的效用，研究人员探索了各种策略，包括将褐藻多酚封装或整合到纳米/微粒或先进的药物递送系统中。本综述全面探讨了褐藻多酚的结构和生物学特性，并提供了有关在临床前和临床应用中有效利用它们的潜在策略的见解。
