Ji Meifeng, Ba Teer, Li Huixia, Wang Dongxue, Zhang Guisen, Wang Wei
Department of retinal disease, Inner Mongolia Chaoju Eye Hospital, Hohhot, China.
School of Public Health, Inner Mongolia Medical University, Hohhot, China.
Photodiagnosis Photodyn Ther. 2025 Apr;52:104499. doi: 10.1016/j.pdpdt.2025.104499. Epub 2025 Jan 30.
In order to evaluate the effectiveness of repeated low-level red-light (RLRL) therapy on stabilizing axial elongation and refractive changes in adolescents with mild to moderate myopia. In addition, we also examined whether RLRL therapy affects retinal blood flow density in the macular region, a factor previously unstudied in this context.
Conducted at a single clinical site, this retrospective, single-arm study followed participants over six months, with assessments at baseline, 1 month, 3 months, and 6 months. The primary outcomes included axial length and spherical equivalent refraction (SER) changes. Secondary assessments included retinal blood flow density (superficial and deep macular layers), white-to-white corneal diameter, central corneal thickness, intraocular pressure (IOP), corneal curvature, light sensitivity, and peripheral retinal thickness.
There were 32 enrolled participants (mean age = 11.5 ± 1.72) in the current study. The spherical equivalent (SER) remained relatively stable over the first three months, but it significantly improved at six months, changing from -2.39 ± 2.21 D at baseline to -2.01 ± 2.12 D (P < 0.05). However, the axial length also showed minimal variation across follow-up visits, indicating stable eye growth with no substantial elongation throughout the study period. Furthermore, RLRL therapy resulted in stable measurements across primary and secondary outcomes (all P > 0.05), with no significant changes over the six months. There were no obvious side effects following the treatment.
Low-energy red light therapy shows promise as a non-invasive approach for stabilizing myopia in adolescents, with no observed compromise to retinal blood flow density. Further longitudinal research is needed to validate these findings and support clinical recommendations for myopia management.
为了评估重复低强度红光（RLRL）疗法对稳定轻度至中度近视青少年眼轴长度和屈光变化的有效性。此外，我们还研究了RLRL疗法是否会影响黄斑区视网膜血流密度，这是此前在此背景下未被研究的一个因素。
本回顾性单臂研究在单一临床地点进行，对参与者进行了为期六个月的随访，在基线、1个月、3个月和6个月时进行评估。主要结局包括眼轴长度和等效球镜度（SER）变化。次要评估包括视网膜血流密度（黄斑浅层和深层）、白对白角膜直径、中央角膜厚度、眼压（IOP）、角膜曲率、光敏感度和周边视网膜厚度。
本研究共纳入32名参与者（平均年龄 = 11.5 ± 1.72）。等效球镜度（SER）在最初三个月相对稳定，但在六个月时显著改善，从基线时的-2.39 ± 2.21 D变为-2.01 ± 2.12 D（P < 0.05）。然而，眼轴长度在随访期间也显示出最小的变化，表明在整个研究期间眼生长稳定，没有明显伸长。此外，RLRL疗法导致主要和次要结局的测量结果稳定（所有P > 0.05），在六个月内没有显著变化。治疗后没有明显的副作用。
低能量红光疗法有望成为一种稳定青少年近视的非侵入性方法，且未观察到对视网膜血流密度的损害。需要进一步的纵向研究来验证这些发现，并支持近视管理的临床建议。
