Gimeno-Santos Elena, Vilaró Jordi, Arbilllaga-Etxarri Ane, Herrero-Cortina Beatriz, Ramon Maria Antonia, Corberó Ana Balañá, Fernández-Domínguez Juan Carlos, Zárate-Tejero Carlos, Barberan-Garcia Anael, Del Corral Tamara, Jiménez-Reguera Begoña, López Asenet, López-Fernández Daniel, Treves Patricia Madrid, Martinez-Alejos Roberto, Muñoz Gerard, Ríos-Cortés Antonio, Ruiz-López Ketty, Miguel-Pagola Marta San, Sánchez-Cayado Natalia, Valeiro Beatriz, Valenza Marie Carmen, Valenza Gerald, Varas Ana Beatriz, Córdoba Silvia, Vega Angeles, Linares Maria, Madrid Eva María, Souto Sonia, Vendrell Montserrat, Garcia-Aymerich Judith
Barcelona of Global Health Institute (ISGlobal), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain.
Facultat Ciències de la Salut Blanquerna, Global Research on Wellbeing (GRoW), Universitat Ramon Llull, Barcelona, Spain.
Arch Bronconeumol. 2025 Aug;61(8):459-466. doi: 10.1016/j.arbres.2025.01.005. Epub 2025 Jan 17.
(i) To develop sex-specific reference equations to predict distance walked (6MWD) in the 6-minute walk test (6MWT), in healthy subjects aged 45-85 years, from different geographic areas of Spain; and (ii) to compare developed equations with previously published in a large sample of COPD patients.
First, a cross-sectional multicentre sample of randomly selected healthy subjects from 17 Spanish hospitals and universities performed two 6MWT. Linear regression and fractional polynomial modelling were used to develop the equations. Second, the developed equations were applied to 715 COPD patients from Spanish primary care centres and hospitals, and the % predicted 6MWD obtained was compared with previously published equations using Dunnett's multiple comparisons test.
568 healthy subjects were included (51% females, mean (SD) age 62 (11) years), walked a 6MWD of 615 (113) and 557 (93)m in males and females, respectively. The developed equations included age, weight and height, and explained 43% and 51% of the 6MWD variance for males and females, respectively. In the COPD sample (n=715, 14% females, 68 (9) years, FEV 61 (18) % predicted, 6MWD 464 (97)m), only 1 out of 9 previously published equations for males, and 6 out of 9 for females predicted 6MWD values similar to those of the newly developed Spanish reference equations.
The newly developed reference equations provide a more valid prediction of 6MWD in Spanish adults with COPD compared to previously published equations. We suggest their use in future research and clinical practice for the Spanish adult population.
（i）建立性别特异性参考方程，用于预测西班牙不同地理区域45 - 85岁健康受试者在6分钟步行试验（6MWT）中的步行距离（6MWD）；（ii）将所建立的方程与先前在大量慢性阻塞性肺疾病（COPD）患者中发表的方程进行比较。
首先，从17家西班牙医院和大学随机选取健康受试者组成横断面多中心样本，进行两次6MWT。采用线性回归和分数多项式建模来建立方程。其次，将所建立的方程应用于来自西班牙初级保健中心和医院的715例COPD患者，并使用Dunnett多重比较检验将获得的预测6MWD百分比与先前发表的方程进行比较。
纳入568例健康受试者（51%为女性，平均（标准差）年龄62（11）岁），男性和女性的6MWD分别为615（113）米和557（93）米。所建立的方程纳入了年龄、体重和身高，分别解释了男性和女性6MWD方差的43%和51%。在COPD样本（n = 715，14%为女性，68（9）岁，第1秒用力呼气容积（FEV）为预测值的61（18）%，6MWD为464（97）米）中，先前发表的9个男性方程中只有1个，9个女性方程中有6个预测的6MWD值与新建立的西班牙参考方程相似。
与先前发表的方程相比，新建立的参考方程能更有效地预测西班牙成年COPD患者的6MWD。我们建议在未来针对西班牙成年人群的研究和临床实践中使用这些方程。
