在癌症试验中最大化宠物狗的双重益处。
Maximizing the dual benefit of pet dogs in cancer trials.
作者信息
Lenz Jennifer A, Atherton Matthew J
机构信息
Department of Clinical Sciences & Advanced Medicine, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, USA.
Department of Biomedical Sciences, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, USA.
出版信息
Nat Rev Cancer. 2025 Mar;25(3):147-148. doi: 10.1038/s41568-025-00792-0.
Abstract
Pet dogs with cancer have catalysed the translation of preclinical discoveries to first-in-human trials, highlighting the unique power of comparative oncology to study veterinary and human patients with cancer in parallel. However, the full potential of this approach has yet to be harnessed. Here we highlight accomplishments in oncology due to trials in dogs and discuss the next steps to advance comparative oncology.
摘要
患有癌症的宠物狗推动了临床前研究成果向首次人体试验的转化，凸显了比较肿瘤学在同时研究患癌兽医和人类患者方面的独特力量。然而，这种方法的全部潜力尚未得到充分利用。在此，我们重点介绍了因犬类试验而在肿瘤学领域取得的成就，并讨论了推进比较肿瘤学的下一步措施。
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