Lin Caixia, Wu Jian, Cao Kai, Wang Bingsong, Fang Yuxin, Kyoko Ohno-Matsui, Sun Yunyun, Hao Jie, Ma Lixia, Zhang Ye, Zhang Qing, Wang Ningli
Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Capital Medical University, No. 1 Dong Jiao Min Xiang Street, Beijing, Dongcheng District, 100730, P.R. China.
Henan Academy of Innovations in Medical Science, Henan, 450008, China.
BMC Ophthalmol. 2025 Jan 31;25(1):55. doi: 10.1186/s12886-025-03874-7.
To describe the prevalence and the cumulative 6-year incidence of fundus tessellation in a rural Chinese adult population.
The Handan Eye Study was a population-based longitudinal study, with 6830 eligible subjects included in the baseline period, and 5394 subjects (follow-up rate: 85.3%) took part in the follow-up study. Participants had detailed eye examinations and physical examinations; a detailed questionnaire was also well administered. Fundus tessellation was defined as well-defined choroidal vessels that can be observed clearly around the fovea as well as around the arcade vessels.
Among 6830 subjects who participated in the baseline study, the prevalence of fundus tessellation was 9.89% (95%CI: 9.22-10.58%). The prevalence of fundus tessellation increased with age; that of subjects aged younger than 50 years and those aged 50 years or older was 2.5% and 14.5%, respectively. Six years later, the cumulative 6-year incidence of fundus tessellation was 1.21% (95%CI: 1.03-1.40%). Similarly, the incidence of fundus tessellation also increased with age; that of participants aged younger than 50 years and those aged 50 years or older was 0.20% and 1.86%, respectively. The progression rate of fundus tessellation in those with fundus tessellation at baseline was 1.5% (95% CI: 0.82%, 2.38%). By multivariable analysis, subjects being older (OR: 1.079, P < 0.001) and havingβ-parapapillary atrophy at baseline (OR: 2.657, P = 0.002) were associated with a higher risk of incidence of fundus tessellation.
The prevalence and 6-year incidence of fundus tessellation were 9.89% and 1.21% in rural Chinese adults aged 30 + years, respectively. The progression rate in participants with fundus tessellation indicates the importance of regular follow-up for these patients.
描述中国农村成年人群中眼底棋盘格样改变的患病率及6年累积发病率。
邯郸眼病研究是一项基于人群的纵向研究，基线期纳入6830名符合条件的受试者，5394名受试者（随访率：85.3%）参与了随访研究。参与者接受了详细的眼科检查和体格检查；还精心管理了一份详细的问卷。眼底棋盘格样改变定义为在黄斑中心凹周围以及视网膜动脉弓周围可清晰观察到的界限分明的脉络膜血管。
在参与基线研究的6830名受试者中，眼底棋盘格样改变的患病率为9.89%（95%CI：9.22 - 10.58%）。眼底棋盘格样改变的患病率随年龄增长而增加；年龄小于50岁和50岁及以上受试者的患病率分别为2.5%和14.5%。6年后，眼底棋盘格样改变的6年累积发病率为1.21%（95%CI：1.03 - 1.40%）。同样，眼底棋盘格样改变的发病率也随年龄增长而增加；年龄小于50岁和50岁及以上参与者的发病率分别为0.20%和1.86%。基线时患有眼底棋盘格样改变者的进展率为1.5%（95%CI：0.82%，2.38%）。通过多变量分析，年龄较大（OR：1.079，P < 0.001）以及基线时存在β - 视乳头旁萎缩（OR：2.657，P = 0.002）的受试者发生眼底棋盘格样改变的风险较高。
30岁及以上中国农村成年人中眼底棋盘格样改变的患病率和6年发病率分别为9.89%和1.21%。眼底棋盘格样改变患者的进展率表明对这些患者进行定期随访的重要性。
